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<p>Human expansion into deep space necessitates sustainable life support. Current prepackaged food systems face nutritional, logistical, and psychological limits on long missions. Cell agriculture, particularly yeast-based biomanufacturing, emerges as a pivotal solution. Yeast’s genetic flexibility, metabolic resilience, and tolerance to extreme conditions make it an ideal chassis for in-situ food and nutrient production. This review systematically explores yeast’s application in creating closed-loop space food systems, analyzing its progress, challenges, and future potential for enabling sustained extraterrestrial presence.</p>

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Yeast-driven biomanufacturing in space: synergizing cellular agriculture for sustainable extraterrestrial habitats

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月23日

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  • Yishu Yin,
  • Heqi Gao,
  • Dan Xiao,
  • Ting Ju,
  • Jiayu Wang,
  • Yuanbing Zhu,
  • Lishui Chen,
  • Weihong Lu

摘要

Human expansion into deep space necessitates sustainable life support. Current prepackaged food systems face nutritional, logistical, and psychological limits on long missions. Cell agriculture, particularly yeast-based biomanufacturing, emerges as a pivotal solution. Yeast’s genetic flexibility, metabolic resilience, and tolerance to extreme conditions make it an ideal chassis for in-situ food and nutrient production. This review systematically explores yeast’s application in creating closed-loop space food systems, analyzing its progress, challenges, and future potential for enabling sustained extraterrestrial presence.