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<p>Our study investigates the effects of long-duration spaceflight on brain aging in spacefarers using structural MRI and machine learning models. Pre-, post-, and follow-up scans of ROS cosmonauts ESA astronauts, and matched Earth-bounding controls were analyzed. We found a considerable difference between the spacefareres and the control group, especially in the ESA cohorts (ß = 0.63). In the ROS cohorts, we observed a difference between the pre- and post-flight scans. A post-hoc analysis revealed that the pre-flight brain age delta was 0.842 years less than the immediate post-flight brain age delta after long-duration spaceflight. All three machine learning models showed good to excellent intraclass correlation coefficients (ICC) between the two consecutive MRI sessions. Our findings suggest that long-duration spaceflight may have an effect on human brain aging as observed from MRI.</p>

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Longitudinal brain-age predictions comprising long-duration spaceflight missions

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月18日

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  • Ge Tang,
  • Kaustubh R. Patil,
  • Felix Hoffstaedter,
  • Shammi More,
  • Simon B. Eickhoff,
  • Steven Jillings,
  • Ben Jeurissen,
  • Elena Tomilovskaya,
  • Darius Gerlach,
  • Inna Nosikova,
  • Alexandra Riabova,
  • Ekaterina Pechenkova,
  • Viktor Petrovichev,
  • Ilya Rukavishnikov,
  • Lyudmila Makovskaya,
  • Angelique Van Ombergen,
  • Floris L. Wuyts,
  • Peter zu Eulenburg

摘要

Our study investigates the effects of long-duration spaceflight on brain aging in spacefarers using structural MRI and machine learning models. Pre-, post-, and follow-up scans of ROS cosmonauts ESA astronauts, and matched Earth-bounding controls were analyzed. We found a considerable difference between the spacefareres and the control group, especially in the ESA cohorts (ß = 0.63). In the ROS cohorts, we observed a difference between the pre- and post-flight scans. A post-hoc analysis revealed that the pre-flight brain age delta was 0.842 years less than the immediate post-flight brain age delta after long-duration spaceflight. All three machine learning models showed good to excellent intraclass correlation coefficients (ICC) between the two consecutive MRI sessions. Our findings suggest that long-duration spaceflight may have an effect on human brain aging as observed from MRI.