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<p>We evaluated the impact of spaceflight on a microphysiologic model of calcium oxalate (CaOx) kidney stone disease. Proximal tubule epithelial cells cultured as confluent microtubules were exposed to CaOx crystals with or without potassium citrate (a potential countermeasure) to determine the impact on gene expression. Nine genes were differentially expressed in response to CaOx crystal exposure during spaceflight. This project presents the use of microgravity as a unique environment to study kidney pathophysiology.</p>

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Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月11日

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  • Kendan Jones-Isaac,
  • Catherine K. Yeung,
  • Jacelyn Bain,
  • Kevin Lidberg,
  • Jade Yang,
  • Lu Wang,
  • James MacDonald,
  • Theo Bammler,
  • Kenneth E. Thummel,
  • Megan Corn,
  • Micaela Vela Ruiz,
  • Stefanie Countryman,
  • Paul Koenig,
  • Henning H. Mann,
  • Jonathan Himmelfarb,
  • Edward J. Kelly

摘要

We evaluated the impact of spaceflight on a microphysiologic model of calcium oxalate (CaOx) kidney stone disease. Proximal tubule epithelial cells cultured as confluent microtubules were exposed to CaOx crystals with or without potassium citrate (a potential countermeasure) to determine the impact on gene expression. Nine genes were differentially expressed in response to CaOx crystal exposure during spaceflight. This project presents the use of microgravity as a unique environment to study kidney pathophysiology.