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<p>Human spaceflight is advancing toward sustainable exploration through initiatives like NASA’s Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome–integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.</p>

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Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月20日

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  • Damian M. Bailey,
  • Dieter Blottner,
  • Hanns-Christian Gunga,
  • Stefan Schneider,
  • Virginia Wotring,
  • Sarah Baatout,
  • Marco Durante,
  • Rik H. G. Olde Engberink,
  • Nandu Goswami,
  • Martina Heer,
  • Anna-Maria Liphardt,
  • Monica Monici,
  • Francesco Pagnini,
  • Claudia Stern,
  • Jan-Bernd Stukenborg,
  • Tobias Weber,
  • Laurence Vico,
  • Olivier White,
  • Angelique van Ombergen,
  • Alexander Choukér

摘要

Human spaceflight is advancing toward sustainable exploration through initiatives like NASA’s Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome–integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.