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<p>Microgravity induces cardiovascular adaptations, including fluid shifts, cardiac remodeling, and autonomic changes. Acute responses involve increased preload and stroke volume, while chronic adaptations include cardiac atrophy, vascular remodeling, and autonomic impairment, contributing to post-flight orthostatic intolerance. These changes raise concerns for long-term astronaut health. Understanding these adaptations is crucial for developing countermeasures to mitigate spaceflight-related cardiovascular risks and may offer insights applicable to terrestrial medicine.</p>

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Review of microgravity’s impact on cardiovascular and nervous systems in space exploration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月30日

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  • Asma A. Alzaabi,
  • Fatema M. Alzaabi,
  • Raqshan Wajih Siddiqui,
  • Tabish Wajih Siddiqui,
  • Manal M. Sami

摘要

Microgravity induces cardiovascular adaptations, including fluid shifts, cardiac remodeling, and autonomic changes. Acute responses involve increased preload and stroke volume, while chronic adaptations include cardiac atrophy, vascular remodeling, and autonomic impairment, contributing to post-flight orthostatic intolerance. These changes raise concerns for long-term astronaut health. Understanding these adaptations is crucial for developing countermeasures to mitigate spaceflight-related cardiovascular risks and may offer insights applicable to terrestrial medicine.