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<p>The surge in commercial and civilian spaceflight enables the systematic and longitudinal, large-scale biospecimen collection to understand the prospective effects of space travel on human health. The Genomics and Space Medicine (Space Omics) project at BCM-HGSC involves a comprehensive biospecimen collection plan from commercial/private space flight participants. The manuscript addresses the critical gaps in the biospecimen collection process including details of the informed consent process, a provision for subjects to obtain custom CLIA-WGS reports, a data dictionary and a LIMS enabled biobank. The manuscript also discusses the biospecimens collection, processing methodologies and nucleic acid suitability for Omics data generation. Results from Axiom-2 mission where, 339 biospecimens were collected using ‘Genomic Evaluation of Space Travel and Research (GENESTAR)’ manual, at two different sites, showed that 98% of the blood samples and 91.6% of the non-blood samples passed the QC requirements for Omics assays, underscoring the reliability and effectiveness of the GENESTAR manual.</p>

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The GENESTAR manual for biospecimen collection biobanking and omics data generation from commercial space missions

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月14日

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  • Aparna Krishnavajhala,
  • Marie-Claude Gingras,
  • Emmanuel Urquieta,
  • Hsu Chao,
  • Dilrukshi Bandaranaike,
  • Yi Chen,
  • Sravya Bhamidipati,
  • Viktoriya Korchina,
  • S. Michelle Griffin,
  • Michal M. Masternak,
  • Hannah Moreno,
  • Javid Mohammed,
  • Mullai Murugan,
  • Jennifer E. Posey,
  • Jimmy H. Wu,
  • Donna Muzny,
  • Richard A. Gibbs,
  • Harsha Doddapaneni

摘要

The surge in commercial and civilian spaceflight enables the systematic and longitudinal, large-scale biospecimen collection to understand the prospective effects of space travel on human health. The Genomics and Space Medicine (Space Omics) project at BCM-HGSC involves a comprehensive biospecimen collection plan from commercial/private space flight participants. The manuscript addresses the critical gaps in the biospecimen collection process including details of the informed consent process, a provision for subjects to obtain custom CLIA-WGS reports, a data dictionary and a LIMS enabled biobank. The manuscript also discusses the biospecimens collection, processing methodologies and nucleic acid suitability for Omics data generation. Results from Axiom-2 mission where, 339 biospecimens were collected using ‘Genomic Evaluation of Space Travel and Research (GENESTAR)’ manual, at two different sites, showed that 98% of the blood samples and 91.6% of the non-blood samples passed the QC requirements for Omics assays, underscoring the reliability and effectiveness of the GENESTAR manual.