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<p>We utilized the <i>K14-Cre Brca1</i><sup><i>f/f</i></sup><i>Tp53</i><sup><i>f/f</i></sup> mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent <i>Brca1</i>-related breast cancer. PARPi alone did not intercept or prevent tumor development. PARPi+AKTi intercepted tumors but did not prevent new tumors. These data confirm the efficacy of a PARPi and an inhibitor of PI3K signaling in treating <i>BRCA1/2</i>-related tumors, but this combination is not sufficient to prevent carcinogenesis.</p>

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Simultaneous inhibition of PARP/AKT to intercept nascent BRCA1/2mut breast tumors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月16日

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  • Lin Wang,
  • Brian R. Sardella,
  • Emily K. Aronson,
  • Zhaoji Liu,
  • Xiaohui Li,
  • Gerburg M. Wulf,
  • Yujing J. Heng

摘要

We utilized the K14-Cre Brca1f/fTp53f/f mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development. PARPi+AKTi intercepted tumors but did not prevent new tumors. These data confirm the efficacy of a PARPi and an inhibitor of PI3K signaling in treating BRCA1/2-related tumors, but this combination is not sufficient to prevent carcinogenesis.