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<p>The NSABP B-51/RTOG 1304 trial represents a paradigm shift in breast cancer management, showing that patients achieving nodal clearance after neoadjuvant chemotherapy derive no added benefit from regional nodal irradiation. These results challenge long-standing practice, promotes de-escalation, and raise biologically significant questions, particularly regarding immunologic mechanisms and clinical subgroup variations.</p>

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Rewriting the radiation playbook: NSABP B-51 and the rise of pathologic precision

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月5日

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  • Mehran Habibi,
  • Bruce G. Haffty,
  • Silvia C. Formenti

摘要

The NSABP B-51/RTOG 1304 trial represents a paradigm shift in breast cancer management, showing that patients achieving nodal clearance after neoadjuvant chemotherapy derive no added benefit from regional nodal irradiation. These results challenge long-standing practice, promotes de-escalation, and raise biologically significant questions, particularly regarding immunologic mechanisms and clinical subgroup variations.