Scholarlink

<p>Epidemiological evidence suggests a bidirectional relationship between periodontitis and osteoporosis, yet the underlying mechanisms remain unclear. In this study, using a mouse model combining ovariectomy-induced osteoporosis and ligature-induced periodontitis, we demonstrated that periodontitis significantly aggravated both alveolar and femoral bone loss, impaired intestinal barrier integrity, and elevated systemic inflammation. Gut microbiota and metabolomic analyses revealed that periodontitis induced distinct alterations in gut microbial composition and intestinal metabolic profiles, potentially contributing to systemic inflammation and bone metabolic dysregulation. Furthermore, fecal microbiota transplantation demonstrated that gut microbiota from periodontitis donors aggravated bone loss and inflammation in recipient mice, whereas microbiota from donors that received periodontal treatment partially alleviated inflammatory responses and skeletal deterioration. Collectively, these findings suggest that periodontitis may aggravate osteoporosis via gut microbiota-mediated mechanisms, highlighting the importance of maintaining oral health to mitigate the adverse impact of periodontitis on systemic bone metabolism.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Periodontitis aggravates bone loss through gut microbiota alterations in ovariectomized mice

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月8日

查看全文
  • Hua Nie,
  • Nannan Wang,
  • Haowei Mao,
  • Yuan Wei,
  • Jun Qian,
  • Rixin Chen,
  • Qiao Yuan,
  • Yin Xiao,
  • Li Zhang,
  • Fuhua Yan

摘要

Epidemiological evidence suggests a bidirectional relationship between periodontitis and osteoporosis, yet the underlying mechanisms remain unclear. In this study, using a mouse model combining ovariectomy-induced osteoporosis and ligature-induced periodontitis, we demonstrated that periodontitis significantly aggravated both alveolar and femoral bone loss, impaired intestinal barrier integrity, and elevated systemic inflammation. Gut microbiota and metabolomic analyses revealed that periodontitis induced distinct alterations in gut microbial composition and intestinal metabolic profiles, potentially contributing to systemic inflammation and bone metabolic dysregulation. Furthermore, fecal microbiota transplantation demonstrated that gut microbiota from periodontitis donors aggravated bone loss and inflammation in recipient mice, whereas microbiota from donors that received periodontal treatment partially alleviated inflammatory responses and skeletal deterioration. Collectively, these findings suggest that periodontitis may aggravate osteoporosis via gut microbiota-mediated mechanisms, highlighting the importance of maintaining oral health to mitigate the adverse impact of periodontitis on systemic bone metabolism.