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<p>The gut microbiome’s metabolome critically shapes drug efficacy and toxicity in hematologic malignancies. This review explores how microbial metabolites influence chemotherapy, immunotherapy, and transplant outcomes, and how they can be harnessed as biomarkers and therapeutic targets. Moving from association to intervention, we outline a pathway toward metabolome-informed precision oncology, transforming the “second genome” into a actionable ally for improved cancer therapy.</p>

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The microbial metabolome: remodeling the therapeutic landscape in hematologic malignancies

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月21日

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  • Liang Zhang,
  • Hamed Soleimani Samarkhazan,
  • Yaseer almajidi,
  • Rushen Gafarov

摘要

The gut microbiome’s metabolome critically shapes drug efficacy and toxicity in hematologic malignancies. This review explores how microbial metabolites influence chemotherapy, immunotherapy, and transplant outcomes, and how they can be harnessed as biomarkers and therapeutic targets. Moving from association to intervention, we outline a pathway toward metabolome-informed precision oncology, transforming the “second genome” into a actionable ally for improved cancer therapy.