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<p>Bacterial enteritis caused by the invasion of <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Typhimurium into the intestinal epithelium is often associated with the overactivation of the immune system, production of proinflammatory cytokines, disruption of the intestinal barrier and dysbiosis of gut microbiota. In this study, the gut commensal <i>Parabacteroides goldsteinii</i> isolated from the feces of mice and enriched after consumption of <i>Hirsutella sinensis mycelium</i> (HSM) was selected to evaluate its ameliorative effect on enteritis. <i>S</i>. <i>typhimurium</i> was used to establish an enteritis model in mice and the effects of orally administered heat-killed <i>P. goldsteinii</i> were evaluated. The results indicated that <i>P. goldsteinii</i> reduced the systemic burdens of <i>S</i>. <i>typhimurium</i>, restored mucosal barrier integrity, decreased overexpression of genes involved in inflammation, and modulated the composition of gut microbiota, leading to the amelioration of enteritis. A subsequent transcriptomic study in germ-free mice highlighted that <i>P. goldsteinii</i> administration increased the expression of α-defensins, Reg3g, lyz1, and CARD9, which are involved in mucosal defense mechanisms. The increased expression of these factors was validated in infected specific-pathogen free (SPF) mice. The results indicated that <i>P. goldsteinii</i> may enhance intestinal immunity, leading to a reduction in <i>S</i>. <i>typhimurium</i> pathogenicity. <i>P. goldsteinii</i> may be developed as a food supplement for the amelioration of <i>S</i>. <i>typhimurium</i> infection-associated enteritis.</p>

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Gut commensal Parabacteroides goldsteinii protects against Salmonella infection in mice by enhancing innate defense function

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月14日

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  • Chien-Chang Chen,
  • Tzu-Lung Lin,
  • Chia-Chen Lu,
  • Kun-Jei Chen,
  • Shih-Ming Jung,
  • Jong-Hwei Su Pang,
  • Hsin-Chih Lai

摘要

Bacterial enteritis caused by the invasion of Salmonella enterica subsp. enterica serovar Typhimurium into the intestinal epithelium is often associated with the overactivation of the immune system, production of proinflammatory cytokines, disruption of the intestinal barrier and dysbiosis of gut microbiota. In this study, the gut commensal Parabacteroides goldsteinii isolated from the feces of mice and enriched after consumption of Hirsutella sinensis mycelium (HSM) was selected to evaluate its ameliorative effect on enteritis. S. typhimurium was used to establish an enteritis model in mice and the effects of orally administered heat-killed P. goldsteinii were evaluated. The results indicated that P. goldsteinii reduced the systemic burdens of S. typhimurium, restored mucosal barrier integrity, decreased overexpression of genes involved in inflammation, and modulated the composition of gut microbiota, leading to the amelioration of enteritis. A subsequent transcriptomic study in germ-free mice highlighted that P. goldsteinii administration increased the expression of α-defensins, Reg3g, lyz1, and CARD9, which are involved in mucosal defense mechanisms. The increased expression of these factors was validated in infected specific-pathogen free (SPF) mice. The results indicated that P. goldsteinii may enhance intestinal immunity, leading to a reduction in S. typhimurium pathogenicity. P. goldsteinii may be developed as a food supplement for the amelioration of S. typhimurium infection-associated enteritis.