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<p>The human gut microbiota is vital for immune function, metabolism, and resistance to pathogens. Soil-transmitted helminths like <i>Trichuris trichiura</i> can disrupt this microbial community, but the extent and functional significance of these disruptions across diverse regions remain unclear. We investigated the impact of <i>T. trichiura</i> infection on gut microbiota composition and function in three endemic regions—Côte d’Ivoire, Laos, and Tanzania—using standardized, high-resolution metagenomic profiling. Our findings reveal consistent depletion of key short-chain fatty acid (SCFA) producers, including <i>Blautia</i> sp. MSJ 9 and <i>Holdemanella biformis</i>, and enrichment of mucin-degrading genera such as <i>Ruminococcus</i> and <i>Bacteroides</i>. These changes coincided with increased microbial utilization of host-derived carbohydrates and destabilization of microbial networks, notably with the emergence of <i>Segatella copri</i> in infected individuals. Although taxa-level responses varied by region, similar trends in SCFA depletion and mucin degradation were observed across sites, pointing to a potentially shared metabolic response to infection. These alterations suggest compromised gut barrier function and immune modulation, potentially promoting parasite persistence. Our results underscore the potential of microbiome-based strategies, such as targeted probiotics or dietary interventions, to support helminth control by restoring microbial balance and improving host resilience.</p>

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Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月21日

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  • Pierre H. H. Schneeberger,
  • Julian Dommann,
  • Nurudeen Rahman,
  • Eveline Hürlimann,
  • Somphou Sayasone,
  • Said Ali,
  • Jean Tenena Coulibaly,
  • Jennifer Keiser

摘要

The human gut microbiota is vital for immune function, metabolism, and resistance to pathogens. Soil-transmitted helminths like Trichuris trichiura can disrupt this microbial community, but the extent and functional significance of these disruptions across diverse regions remain unclear. We investigated the impact of T. trichiura infection on gut microbiota composition and function in three endemic regions—Côte d’Ivoire, Laos, and Tanzania—using standardized, high-resolution metagenomic profiling. Our findings reveal consistent depletion of key short-chain fatty acid (SCFA) producers, including Blautia sp. MSJ 9 and Holdemanella biformis, and enrichment of mucin-degrading genera such as Ruminococcus and Bacteroides. These changes coincided with increased microbial utilization of host-derived carbohydrates and destabilization of microbial networks, notably with the emergence of Segatella copri in infected individuals. Although taxa-level responses varied by region, similar trends in SCFA depletion and mucin degradation were observed across sites, pointing to a potentially shared metabolic response to infection. These alterations suggest compromised gut barrier function and immune modulation, potentially promoting parasite persistence. Our results underscore the potential of microbiome-based strategies, such as targeted probiotics or dietary interventions, to support helminth control by restoring microbial balance and improving host resilience.