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<p>The quorum-sensing molecule 3,5-dimethylpyrazine-2-ol (DPO), known for regulating biofilm formation in <i>Vibrio cholerae</i>, has unknown distribution among commensal bacteria. We screened 37 bacterial strains using a validated biosensor and found widespread production. Inoculating mice with high producers elevated gut DPO levels, highlighting DPO’s potential influence on gut microbiota. These findings expand DPO’s ecological relevance and underscore quorum sensing as a potentially critical influence on microbiome function and host-microbe interactions.</p>

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DPO production by gut commensals suggests a broader role in bacterial communication and host-microbiome interactions

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月28日

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  • Michael Moraskie,
  • Sara Li,
  • Josep-Ramon Codina,
  • Md Harun Or Roshid,
  • Kevin Núño,
  • Gregory O’Connor,
  • Emre Dikici,
  • Sapna Deo,
  • Eleonore Beurel,
  • Sylvia Daunert

摘要

The quorum-sensing molecule 3,5-dimethylpyrazine-2-ol (DPO), known for regulating biofilm formation in Vibrio cholerae, has unknown distribution among commensal bacteria. We screened 37 bacterial strains using a validated biosensor and found widespread production. Inoculating mice with high producers elevated gut DPO levels, highlighting DPO’s potential influence on gut microbiota. These findings expand DPO’s ecological relevance and underscore quorum sensing as a potentially critical influence on microbiome function and host-microbe interactions.