Scholarlink

<p>Human milk microbiota (HMM) plays a key role in infant gut microbiota (IGM) establishment, however, the influence of the early life HMM in later neurodevelopment remains unclear. In this mother-infant cohort, we investigated HMM development and its impact on IGM-neurodevelopment crosstalk. Breast milk and infant feces were collected on days 0, 7, and 30 for sequencing and SCFAs quantification, while neurodevelopment was assessed via ASQ-3 at 12 months. HMM remained stable during the first month, while IGM fluctuated significantly within the first 7 days. Songbird and mediation analyses revealed strengthening associations between HMM, IGM, and neurodevelopment over time. IGM served as a key mediator linking HMM to neurodevelopment, with SCFAs playing a mediating role in the connection between IGM and neurodevelopment on day 30. Our findings suggest that early-life stable and unique HMM may influence long-term neurodevelopment by dynamically modulating IGM and SCFAs, highlighting a potential strategy to prevent neurodysplasia by monitoring mother-infant microecology.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Infant gut microbiota and SCFAs mediate the association between early-life human milk microbiota and neurodevelopment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月1日

查看全文
  • Simou Wu,
  • Wen Jia,
  • Jinxing Li,
  • Yating Luo,
  • Fei Chen,
  • Ting Yang,
  • Xia Jiang,
  • Fang He,
  • Ruyue Cheng

摘要

Human milk microbiota (HMM) plays a key role in infant gut microbiota (IGM) establishment, however, the influence of the early life HMM in later neurodevelopment remains unclear. In this mother-infant cohort, we investigated HMM development and its impact on IGM-neurodevelopment crosstalk. Breast milk and infant feces were collected on days 0, 7, and 30 for sequencing and SCFAs quantification, while neurodevelopment was assessed via ASQ-3 at 12 months. HMM remained stable during the first month, while IGM fluctuated significantly within the first 7 days. Songbird and mediation analyses revealed strengthening associations between HMM, IGM, and neurodevelopment over time. IGM served as a key mediator linking HMM to neurodevelopment, with SCFAs playing a mediating role in the connection between IGM and neurodevelopment on day 30. Our findings suggest that early-life stable and unique HMM may influence long-term neurodevelopment by dynamically modulating IGM and SCFAs, highlighting a potential strategy to prevent neurodysplasia by monitoring mother-infant microecology.