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<p>The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic (<i>n</i> = 596) and immune profiling (<i>n</i> = 314) data, we show that the B blood group phenotype associates with increased risk of sPTB and adverse vaginal microbiota composition. The O blood group associates with sPTB in women who have a combination of a previous history of sPTB, an adverse vaginal microbial composition and pro-inflammatory cervicovaginal <i>milieu</i>. In contrast, women of blood group A have a higher prevalence of vaginal <i>Lactobacillus crispatus</i>, a lower risk of sPTB, with sPTB cases showing no association with vaginal microbiota composition or inflammation. We found that cervicovaginal fluid contains ABH(O) glycans and shows variable binding to key vaginal bacteria. This indicates that cervicovaginal ABH(O) glycans influence microbiota-host interactions implicated in sPTB risk, suggesting a novel target for sPTB prediction and prevention.</p>

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ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月10日

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  • Katherine E. Mountain,
  • David A. MacIntyre,
  • Yun S. Lee,
  • Virginia Tajadura-Ortega,
  • Anne Dell,
  • Stuart M. Haslam,
  • Gang Wu,
  • Paola Grassi,
  • Ten Feizi,
  • Yan Liu,
  • Wengang Chai,
  • Julian R. Marchesi,
  • Lauren A. Roberts,
  • Denise Chan,
  • Belen Gimeno-Molina,
  • Richard G. Brown,
  • Holly V. Lewis,
  • Alice K. C. Hyde,
  • James Pasint-Magyar,
  • Anna Green,
  • Anna L. David,
  • Jane E. Norman,
  • Sarah J. Stock,
  • Samit Kundu,
  • Sherrianne Ng,
  • Ben Glampson,
  • Erik Mayer,
  • TG Teoh,
  • Vasso Terzidou,
  • Phillip R. Bennett,
  • Lynne Sykes

摘要

The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic (n = 596) and immune profiling (n = 314) data, we show that the B blood group phenotype associates with increased risk of sPTB and adverse vaginal microbiota composition. The O blood group associates with sPTB in women who have a combination of a previous history of sPTB, an adverse vaginal microbial composition and pro-inflammatory cervicovaginal milieu. In contrast, women of blood group A have a higher prevalence of vaginal Lactobacillus crispatus, a lower risk of sPTB, with sPTB cases showing no association with vaginal microbiota composition or inflammation. We found that cervicovaginal fluid contains ABH(O) glycans and shows variable binding to key vaginal bacteria. This indicates that cervicovaginal ABH(O) glycans influence microbiota-host interactions implicated in sPTB risk, suggesting a novel target for sPTB prediction and prevention.