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<p>Indian immigration to westernized countries has recently surged, increasing their risk of Inflammatory Bowel Disease (IBD) post-migration. While crucial for understanding IBD risk, the gut microbiome remains understudied in Indians. This cross-sectional study examines the impact of westernization on the gut microbiomes of Indians residing in India, Indo-Immigrants, and Indo-Canadians compared to Euro-Canadian and Euro-Immigrant controls. Stool samples for 16S rRNA and shotgun sequencing assessed microbial taxa and functional profiles, alongside dietary and demographic data to evaluate lifestyle patterns. Indians and Indo-Immigrants had distinct microbiotas from controls, with high abundances of <i>Prevotella</i> spp. and CAZymes reflecting their high complex carbohydrate diet. Indo-Canadians exhibited a transitional microbiome towards westernization, mirroring increasing dietary acculturation. Considering 44% of Canadians are first- and second-generation immigrants and the global adoption of westernized practices, future research should investigate the health implications of such microbiome transitions in immigrant populations and newly industrialized nations.</p>

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The adoption of a westernized gut microbiome in Indian Immigrants and Indo-Canadians is associated with dietary acculturation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月3日

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  • Leah D. D’Aloisio,
  • Mamatha Ballal,
  • Sanjoy Ghosh,
  • Natasha Haskey,
  • Nijiati Abulizi,
  • Ramin Karimianghadim,
  • Chuyi Liu,
  • Pacha Sruthi,
  • Lakshmipriya Nagarajan,
  • Sudha Vasudevan,
  • Vignesh Shetty,
  • Mrudgandha Purandare,
  • Ushasi Bhaumik,
  • Debaki Ranjan Howlader,
  • Sepideh Pakpour,
  • Jacqueline Barnett,
  • Deanna L. Gibson

摘要

Indian immigration to westernized countries has recently surged, increasing their risk of Inflammatory Bowel Disease (IBD) post-migration. While crucial for understanding IBD risk, the gut microbiome remains understudied in Indians. This cross-sectional study examines the impact of westernization on the gut microbiomes of Indians residing in India, Indo-Immigrants, and Indo-Canadians compared to Euro-Canadian and Euro-Immigrant controls. Stool samples for 16S rRNA and shotgun sequencing assessed microbial taxa and functional profiles, alongside dietary and demographic data to evaluate lifestyle patterns. Indians and Indo-Immigrants had distinct microbiotas from controls, with high abundances of Prevotella spp. and CAZymes reflecting their high complex carbohydrate diet. Indo-Canadians exhibited a transitional microbiome towards westernization, mirroring increasing dietary acculturation. Considering 44% of Canadians are first- and second-generation immigrants and the global adoption of westernized practices, future research should investigate the health implications of such microbiome transitions in immigrant populations and newly industrialized nations.