Scholarlink

<p>Mitochondria employ quality control mechanisms to maintain homeostasis. Under chronic stress, these systems become overwhelmed, causing intramitochondrial aggregates formation. As a potential quality control process when canonical pathways are compromised, we propose a model of mitochondrial lipofuscinogenesis where organelles sequester oxidized components into solid inclusions. Observed in neurodegenerative and mitochondrial disease models, this mechanism highlights potential therapeutic targets, although further research is required to elucidate the aggregates’ molecular composition.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mitochondrial aggregates as a novel quality control mechanism and potential relationship to lipofuscinogenesis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月31日

查看全文
  • Paula Cilleros-Holgado,
  • Alejandra López-Cabrera,
  • Rocío Piñero-Pérez,
  • David Gómez-Fernández,
  • José Manuel Romero-Domínguez,
  • Mónica Álvarez-Córdoba,
  • Diana Reche-López,
  • Ana Romero-González,
  • Susana González-Granero,
  • José Manuel García-Verdugo,
  • José Antonio Sánchez-Alcázar

摘要

Mitochondria employ quality control mechanisms to maintain homeostasis. Under chronic stress, these systems become overwhelmed, causing intramitochondrial aggregates formation. As a potential quality control process when canonical pathways are compromised, we propose a model of mitochondrial lipofuscinogenesis where organelles sequester oxidized components into solid inclusions. Observed in neurodegenerative and mitochondrial disease models, this mechanism highlights potential therapeutic targets, although further research is required to elucidate the aggregates’ molecular composition.