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<p>Vascular aging is characterized by endothelial senescence and vascular smooth muscle cell (VSMC) phenotypic switching, yet the role of endothelial extracellular vesicles (EVs) in these processes remains unclear. We show that EVs from non-senescent endothelial cells prevent PDGF-BB–induced VSMC dedifferentiation, preserving contractile markers and limiting migration. In endothelial cells, EVs protected against TNF-α–induced eNOS downregulation but failed to reverse inflammatory and mitochondrial features of senescence after short-term exposure, highlighting a context-dependent protective role.</p>

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Endothelial extracellular vesicles preserve vascular smooth muscle cell identity but do not reverse endothelial senescence

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月26日

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  • Úrsula Zúñiga-Cuevas,
  • Vania Otárola-Urrutia,
  • Leslye Venegas-Zamora,
  • Magda C. Díaz-Vesga,
  • Camila López-Torres,
  • Javiera Favi-Coloma,
  • Constanza Rimassa-Taré,
  • Ximena Calle-Chalco,
  • Andrés Ramírez-Reyes,
  • Alejandra Hernández,
  • Danica Jiménez-Gallegos,
  • Sebastián Urquiza-Zurich,
  • Mayarling F. Troncoso,
  • Ignacio Norambuena-Soto,
  • Mario Chiong,
  • Valentina Parra,
  • Sergio Lavandero,
  • Jaime A. Riquelme

摘要

Vascular aging is characterized by endothelial senescence and vascular smooth muscle cell (VSMC) phenotypic switching, yet the role of endothelial extracellular vesicles (EVs) in these processes remains unclear. We show that EVs from non-senescent endothelial cells prevent PDGF-BB–induced VSMC dedifferentiation, preserving contractile markers and limiting migration. In endothelial cells, EVs protected against TNF-α–induced eNOS downregulation but failed to reverse inflammatory and mitochondrial features of senescence after short-term exposure, highlighting a context-dependent protective role.