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<p>The aging population experiences concurrent brain aging and deterioration of bone health. Imaging-derived brain age gap (BAG) demonstrates enhanced predictive capacity for age-related pathologies compared to chronological age. This study included 28,705 participants who underwent brain MRI at a mean age of 63.2 years, with brain age predicted from 1705 imaging-derived phenotypes using LASSO regression (mean predicted brain age: 63.2 years). We then assessed the associations of BAG with BMD at 4 sites and fracture risks. Each 1-year increase in BAG was associated with reduced femoral neck BMD, femoral trochanter BMD, lumbar spine BMD, total body BMD (<i>β</i>(SE) = −0.0028 (0.0003), <i>P</i> = 7.31E − 21; <i>β</i>(SE) = −0.0031 (0.0003), <i>P</i> = 4.04E − 26; <i>β</i>(SE) = −0.0036 (0.0004), <i>P</i> = 1.30E − 16; <i>β</i>(SE) = −0.0033 (0.0002), <i>P</i> = 3.51E − 36, respectively), and increased risks of all-site fractures (HR 1.06, 95% CI: 1.02–1.10). Sex and menopausal status significantly modified the association between BAG and BMD. Findings suggest that higher BAG was associated with lower BMD and higher all-site fracture risk, and these associations may be stronger in men and postmenopausal women.</p>

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Association of brain age gap with BMD and incident fractures in the UK Biobank

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月13日

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  • Jiong Liu,
  • Lishan Cai,
  • Peixuan Li,
  • Ziyi Wang,
  • Zhilin Huang,
  • Chunxue Yang,
  • Lu Qi,
  • Tao Zhou

摘要

The aging population experiences concurrent brain aging and deterioration of bone health. Imaging-derived brain age gap (BAG) demonstrates enhanced predictive capacity for age-related pathologies compared to chronological age. This study included 28,705 participants who underwent brain MRI at a mean age of 63.2 years, with brain age predicted from 1705 imaging-derived phenotypes using LASSO regression (mean predicted brain age: 63.2 years). We then assessed the associations of BAG with BMD at 4 sites and fracture risks. Each 1-year increase in BAG was associated with reduced femoral neck BMD, femoral trochanter BMD, lumbar spine BMD, total body BMD (β(SE) = −0.0028 (0.0003), P = 7.31E − 21; β(SE) = −0.0031 (0.0003), P = 4.04E − 26; β(SE) = −0.0036 (0.0004), P = 1.30E − 16; β(SE) = −0.0033 (0.0002), P = 3.51E − 36, respectively), and increased risks of all-site fractures (HR 1.06, 95% CI: 1.02–1.10). Sex and menopausal status significantly modified the association between BAG and BMD. Findings suggest that higher BAG was associated with lower BMD and higher all-site fracture risk, and these associations may be stronger in men and postmenopausal women.