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<p>Dietary restriction may extend lifespan by improving late-life gut health. Because micronutrients mediate the effects of macronutrient ratios on longevity, we examined how cholesterol limitation affects gut health in female <i>Drosophila melanogaster</i>. Low-cholesterol diets increased intestinal permeability and reduced lifespan, however, not all flies lost barrier function before dying. This indicates gut dysfunction is either a marker of ageing, or contributes to death, but predominantly during dietary cholesterol limitation.</p>

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Short lifespan under dietary cholesterol depletion is associated with gut dysfunction in Drosophila melanogaster females

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月19日

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  • Brooke Zanco,
  • Christen K. Mirth,
  • Carla M. Sgrò,
  • Matthew D. W. Piper

摘要

Dietary restriction may extend lifespan by improving late-life gut health. Because micronutrients mediate the effects of macronutrient ratios on longevity, we examined how cholesterol limitation affects gut health in female Drosophila melanogaster. Low-cholesterol diets increased intestinal permeability and reduced lifespan, however, not all flies lost barrier function before dying. This indicates gut dysfunction is either a marker of ageing, or contributes to death, but predominantly during dietary cholesterol limitation.