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<p>Senolytic drugs raise the expectation that they can specifically eliminate a subset of senescent cells in a given tissue. In this study, we have exemplarily analyzed if a 3-day treatment of human blood samples in vitro would reduce age-associated biomarkers, with a particular focus on epigenetic age-predictions. Of eight tested compounds, JQ1, RG7112, nutlin-3a, and AMG232 reduced epigenetic age, indicating that this approach may be useful in drug screening for senolytic compounds.</p>

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Senolytic compounds reduce epigenetic age of blood samples in vitro

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月4日

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  • Vithurithra Tharmapalan,
  • Miriam Du Marchie Sarvaas,
  • Michael Bleichert,
  • Martina Wessiepe,
  • Wolfgang Wagner

摘要

Senolytic drugs raise the expectation that they can specifically eliminate a subset of senescent cells in a given tissue. In this study, we have exemplarily analyzed if a 3-day treatment of human blood samples in vitro would reduce age-associated biomarkers, with a particular focus on epigenetic age-predictions. Of eight tested compounds, JQ1, RG7112, nutlin-3a, and AMG232 reduced epigenetic age, indicating that this approach may be useful in drug screening for senolytic compounds.