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<p>Neuronal subtype-specific synaptopathy is a hallmark of many forms of neurodegeneration. We examined the cellular basis for synaptic vulnerability in the auditory system, where three subtypes of spiral ganglion neurons (SGNs)—Ia, Ib, and Ic—carry acoustic information from the cochlea to the brain. In response to noise and aging, a subset of synapses between inner hair cells and SGNs are lost, but it is unclear how this loss varies across SGN subtypes. Using genetic labeling, we showed that Ia SGNs have larger post-synaptic densities (PSDs) than Ib and Ic SGNs and are the most resilient subtype. Ia PSD volumes increase with age and are unchanged after noise exposure. By contrast, average Ib/Ic PSD volumes do not change with age but decrease with noise. Genetic reprogramming of Ib/Ic neurons to a Ia-like identity provides significant protection against noise-induced synaptopathy, linking identity to resilience and providing an entry point for therapeutics.</p>

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Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月10日

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  • Joy A. Franco,
  • Taylor G. Copeland,
  • Ryan D. Merrow,
  • Lisa V. Goodrich

摘要

Neuronal subtype-specific synaptopathy is a hallmark of many forms of neurodegeneration. We examined the cellular basis for synaptic vulnerability in the auditory system, where three subtypes of spiral ganglion neurons (SGNs)—Ia, Ib, and Ic—carry acoustic information from the cochlea to the brain. In response to noise and aging, a subset of synapses between inner hair cells and SGNs are lost, but it is unclear how this loss varies across SGN subtypes. Using genetic labeling, we showed that Ia SGNs have larger post-synaptic densities (PSDs) than Ib and Ic SGNs and are the most resilient subtype. Ia PSD volumes increase with age and are unchanged after noise exposure. By contrast, average Ib/Ic PSD volumes do not change with age but decrease with noise. Genetic reprogramming of Ib/Ic neurons to a Ia-like identity provides significant protection against noise-induced synaptopathy, linking identity to resilience and providing an entry point for therapeutics.