Scholarlink

<p>Domestic pigs are both a globally important agricultural species and an increasingly valuable biomedical model that bridges the gap between rodents and non-human primates. Thus, a thorough understanding of the developing porcine immune system is important to improve pig health and advance preclinical research. Here, we coupled single-cell transcriptomic analyses with T and B cell receptor profiling to create a comprehensive cell atlas of pig hematopoietic development across fetal liver, bone marrow, and thymus tissues from fetal to adult life. We highlight tissue-specific and age-related features; identify gene modules underlying B cell and T cell development; describe the maturation and diversification of B and T cell receptor repertoires in bone marrow B cells and thymic αβ and γδ T cells; and distinguish transcriptionally distinct subsets of γδ T cells according to their γ chain usage. Our data provide key insights into pig immune system development and contribute a valuable resource for advancing pigs as a model of human blood and immune diseases.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A single-cell atlas of porcine hematopoietic development

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月8日

查看全文
  • Weihong Gu,
  • Yuhan Wen,
  • Yi Huang,
  • Shah Jungy Ibna Karim,
  • Alyssa May,
  • Laurie Touchard,
  • Wesley C. Warren,
  • John P. Driver

摘要

Domestic pigs are both a globally important agricultural species and an increasingly valuable biomedical model that bridges the gap between rodents and non-human primates. Thus, a thorough understanding of the developing porcine immune system is important to improve pig health and advance preclinical research. Here, we coupled single-cell transcriptomic analyses with T and B cell receptor profiling to create a comprehensive cell atlas of pig hematopoietic development across fetal liver, bone marrow, and thymus tissues from fetal to adult life. We highlight tissue-specific and age-related features; identify gene modules underlying B cell and T cell development; describe the maturation and diversification of B and T cell receptor repertoires in bone marrow B cells and thymic αβ and γδ T cells; and distinguish transcriptionally distinct subsets of γδ T cells according to their γ chain usage. Our data provide key insights into pig immune system development and contribute a valuable resource for advancing pigs as a model of human blood and immune diseases.