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<p>Guided bone regeneration using double-layered membranes is often hindered by poor interfacial integration, insufficient stability, and limited adaptability to regulate the complex healing process. Herein, we develop a unified bilayer membrane featuring a reinforced dual-crosslinking interface between barrier and porous layers through a homogeneous isomeric in-situ fabrication strategy. Its superior mechanical strength (~156 MPa in dry state and ~8.6 MPa in wet state) ensures the long-term degradation stability and bioactivity in vivo. Combined with sequentially released bioactive components, we show that the unified bilayer membrane regulates antibacterial functions, immunomodulation, neurovascularization, and osteogenesis, thereby enabling stage-adaptive bone regeneration. We test in a <i>rat</i> critical-sized cranial defect model to demonstrate that the membrane significantly outperforms the clinical collagen membrane, achieving ~2.7-fold greater bone volume regeneration after 8 weeks. This work further elucidates the spatiotemporal osteogenic mechanisms of the unified bilayer membrane, which constructs a well-integrated regenerative microenvironment and promotes a tightly interconnected neurovascular-osteogenic communication network during stage-adaptive bone repair.</p>

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Unified bilayer membranes with mechanically reinforced interface for stage-adaptive bone regeneration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月30日

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  • Yuhan Du,
  • Yangyi Nie,
  • Zhiheng Luo,
  • Junjie Deng,
  • Zili Xu,
  • Yuyang Zhang,
  • Chenyu Gao,
  • Yujie Liu,
  • Xiangcheng Lei,
  • Jing Long,
  • Cairong Li,
  • Zhenyu Yao,
  • Wei Zhang,
  • Ling Qin,
  • Yuanchi Zhang,
  • Yuxiao Lai

摘要

Guided bone regeneration using double-layered membranes is often hindered by poor interfacial integration, insufficient stability, and limited adaptability to regulate the complex healing process. Herein, we develop a unified bilayer membrane featuring a reinforced dual-crosslinking interface between barrier and porous layers through a homogeneous isomeric in-situ fabrication strategy. Its superior mechanical strength (~156 MPa in dry state and ~8.6 MPa in wet state) ensures the long-term degradation stability and bioactivity in vivo. Combined with sequentially released bioactive components, we show that the unified bilayer membrane regulates antibacterial functions, immunomodulation, neurovascularization, and osteogenesis, thereby enabling stage-adaptive bone regeneration. We test in a rat critical-sized cranial defect model to demonstrate that the membrane significantly outperforms the clinical collagen membrane, achieving ~2.7-fold greater bone volume regeneration after 8 weeks. This work further elucidates the spatiotemporal osteogenic mechanisms of the unified bilayer membrane, which constructs a well-integrated regenerative microenvironment and promotes a tightly interconnected neurovascular-osteogenic communication network during stage-adaptive bone repair.