Scholarlink

<p>Hippocampal place cells (PCs) are important for spatial coding and episodic memory. PCs’ representations are modulated upon transitioning between environments (global remapping) but also change with repeated exposure to familiar spaces (representational drift). To gain insights into the mechanistic basis for this unique balance between circuit plasticity and stability, we used voltage imaging to longitudinally record the subthreshold and spiking activity of pyramidal neurons (PNs) and somatostatin-positive interneurons (SSTs) within mouse hippocampal CA1 during virtual navigation. A fraction of cells from both populations showed spatial tuning, and many SSTs were speed-tuned or fired uniformly across space. Intracellular recordings revealed increased theta power and asymmetric ramp-like depolarization in PN place fields, while SSTs exhibited symmetric depolarization with no theta increase. Longitudinal recordings across weeks demonstrated representational drifts in both populations, although SSTs exhibited remarkably stable firing and subthreshold properties. Transition to a novel environment induced remapping in both populations, accompanied by&#xa0;an increase in SST activity and&#xa0;a reduction in PN activity. These results provide insights into how hippocampal circuits balance representational stability with experience-dependent plasticity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月1日

查看全文
  • Rotem Kipper,
  • Yaniv Melamed,
  • Qixin Yang,
  • Gal Shturm,
  • Shulamit Baror-Sebban,
  • Yoav Adam

摘要

Hippocampal place cells (PCs) are important for spatial coding and episodic memory. PCs’ representations are modulated upon transitioning between environments (global remapping) but also change with repeated exposure to familiar spaces (representational drift). To gain insights into the mechanistic basis for this unique balance between circuit plasticity and stability, we used voltage imaging to longitudinally record the subthreshold and spiking activity of pyramidal neurons (PNs) and somatostatin-positive interneurons (SSTs) within mouse hippocampal CA1 during virtual navigation. A fraction of cells from both populations showed spatial tuning, and many SSTs were speed-tuned or fired uniformly across space. Intracellular recordings revealed increased theta power and asymmetric ramp-like depolarization in PN place fields, while SSTs exhibited symmetric depolarization with no theta increase. Longitudinal recordings across weeks demonstrated representational drifts in both populations, although SSTs exhibited remarkably stable firing and subthreshold properties. Transition to a novel environment induced remapping in both populations, accompanied by an increase in SST activity and a reduction in PN activity. These results provide insights into how hippocampal circuits balance representational stability with experience-dependent plasticity.