Scholarlink

<p>Locomotion in complex environments requires precise timing and control of paw movements to adapt steps and coordinate limbs. The cerebellum is thought to support moment-to-moment prediction and correction of these movements, but how its cortical neurons encode paw dynamics during locomotion requiring step-specific adjustments remains unclear. We developed LocoReach, a task in which mice walk on a runged treadmill, requiring each step to reach for the next rung. With training, mice improved performance, showing fewer missteps, longer strides, and faster swings. Optogenetic disruption of cerebellar activity shortened swing duration, highlighting the online contribution of lobule simplex. Electrophysiological recordings revealed that molecular layer interneurons and Purkinje cells exhibited activity changes around swing-stance transitions, primarily for the ipsilateral paw but also across multiple paws. Notably, interneurons showed larger responses during longer strides acquired through learning. These findings indicate that cerebellar activity is precisely aligned to step-cycle events, supporting adaptive locomotor control.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Cerebellar activity is triggered by reach endpoint during learning of a complex locomotor task

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月20日

查看全文
  • Andry Andrianarivelo,
  • Heike Stein,
  • Jeremy Gabillet,
  • Clarisse Batifol,
  • Abdelali Jalil,
  • N. Alex Cayco Gajic,
  • Michael Graupner

摘要

Locomotion in complex environments requires precise timing and control of paw movements to adapt steps and coordinate limbs. The cerebellum is thought to support moment-to-moment prediction and correction of these movements, but how its cortical neurons encode paw dynamics during locomotion requiring step-specific adjustments remains unclear. We developed LocoReach, a task in which mice walk on a runged treadmill, requiring each step to reach for the next rung. With training, mice improved performance, showing fewer missteps, longer strides, and faster swings. Optogenetic disruption of cerebellar activity shortened swing duration, highlighting the online contribution of lobule simplex. Electrophysiological recordings revealed that molecular layer interneurons and Purkinje cells exhibited activity changes around swing-stance transitions, primarily for the ipsilateral paw but also across multiple paws. Notably, interneurons showed larger responses during longer strides acquired through learning. These findings indicate that cerebellar activity is precisely aligned to step-cycle events, supporting adaptive locomotor control.