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<p>Few studies have characterized immune correlates of SARS-CoV-2 infection risk in children, particularly those with hybrid immunity from vaccination and prior infection. We conduct a prospective community-based cohort study of 1509 U.S. children (2022–2024), performing weekly SARS-CoV-2 PCR testing and measuring baseline binding and neutralizing antibody titers against multiple variants. Higher antibody levels, notably nucleocapsid-binding and Omicron-specific neutralizing antibodies, are significantly associated with reduced risk of SARS-CoV-2 infection after adjusting for age, recent infection, exposure settings, and temporal trends (adjusted hazard ratios ranging from 0.60 to 0.87 per positive unit difference in log<sub>10</sub>-fold antibody level (AU/mL)). Secondary analyses suggest these findings are robust to multiple stratifications of SARS-CoV-2 immune status, are relevant across different pediatric age groups, and appear to apply to both overall and symptomatic infection risk. Together, the results suggest that specific antibodies can predict relative infection risk in pediatric populations with diverse immune histories. Understanding these immune correlates may inform tailored vaccination strategies and risk assessments as SARS-CoV-2 continues to evolve.</p>

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Immune correlates of risk for SARS-CoV-2 infection in children: a prospective, community-based cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月18日

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  • Katherine L. Hoffman,
  • Grace Marshall,
  • Collrane Frivold,
  • Zack Acker,
  • Isabel S. Arnould,
  • Tara M. Babu,
  • Sarina R. Barnes,
  • Melissa Briggs-Hagen,
  • Amanda Casto,
  • Erica Clark,
  • Sarah N. Cox,
  • Mark Drummond,
  • Brenna Ehmen,
  • Janet A. Englund,
  • Luis Gamboa,
  • Alexander L. Greninger,
  • Sally Grindstaff,
  • Hanna Grioni,
  • Peter Han,
  • Tara Hatchie,
  • Madison Hollcroft,
  • Jennifer L. Kuntz,
  • Natalie K. Lo,
  • Christine M. Lockwood,
  • Kaden D. McAllister,
  • Carter J. McCormick,
  • Melissa P. MacMillan,
  • Claire M. Midgley,
  • Daniel Nguyen,
  • Ian D. Plumb,
  • Jonathan C. Reed,
  • Sacha Reich,
  • Pavitra Roychoudhury,
  • Mark Schmidt,
  • Lea M. Starita,
  • Jeremy Stone,
  • Alexandra Varga,
  • Ana A. Weil,
  • Charles J. Wolock,
  • Neil Yetz,
  • Peter B. Gilbert,
  • Allison L. Naleway,
  • Helen Y. Chu,
  • Marco Carone

摘要

Few studies have characterized immune correlates of SARS-CoV-2 infection risk in children, particularly those with hybrid immunity from vaccination and prior infection. We conduct a prospective community-based cohort study of 1509 U.S. children (2022–2024), performing weekly SARS-CoV-2 PCR testing and measuring baseline binding and neutralizing antibody titers against multiple variants. Higher antibody levels, notably nucleocapsid-binding and Omicron-specific neutralizing antibodies, are significantly associated with reduced risk of SARS-CoV-2 infection after adjusting for age, recent infection, exposure settings, and temporal trends (adjusted hazard ratios ranging from 0.60 to 0.87 per positive unit difference in log10-fold antibody level (AU/mL)). Secondary analyses suggest these findings are robust to multiple stratifications of SARS-CoV-2 immune status, are relevant across different pediatric age groups, and appear to apply to both overall and symptomatic infection risk. Together, the results suggest that specific antibodies can predict relative infection risk in pediatric populations with diverse immune histories. Understanding these immune correlates may inform tailored vaccination strategies and risk assessments as SARS-CoV-2 continues to evolve.