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<p>The blood plasma proteome is a rich reservoir of potential biomarkers, yet its analysis is hindered by a protein concentration dynamic range exceeding ten orders of magnitude. Traditional fractionation and enrichment methods often present limitations in detecting rare proteins masked by the presence of abundant proteins. A promising frontier technology has emerged to overcome such limitations: leveraging nanoparticle protein coronas to enrich low-abundance plasma proteins and unveil previously inaccessible layers of the proteome. This <i>Perspective</i> highlights the capabilities of the protein corona technology in enhancing proteome coverage, addresses its current limitations and outlines future directions in proteoform analysis and causal inference.</p>

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Leveraging nanoparticle protein corona to advance plasma proteome profiling

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月15日

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  • Amir Ata Saei,
  • Bahareh Ghaffari,
  • Borzoo Bonakdarpour,
  • Liangliang Sun,
  • Ying Ge,
  • David R. Nisbet,
  • Vahid Serpooshan,
  • Kostas Kostarelos,
  • Babak Borhan,
  • Catherine J. Murphy,
  • Frank Caruso,
  • Morteza Mahmoudi

摘要

The blood plasma proteome is a rich reservoir of potential biomarkers, yet its analysis is hindered by a protein concentration dynamic range exceeding ten orders of magnitude. Traditional fractionation and enrichment methods often present limitations in detecting rare proteins masked by the presence of abundant proteins. A promising frontier technology has emerged to overcome such limitations: leveraging nanoparticle protein coronas to enrich low-abundance plasma proteins and unveil previously inaccessible layers of the proteome. This Perspective highlights the capabilities of the protein corona technology in enhancing proteome coverage, addresses its current limitations and outlines future directions in proteoform analysis and causal inference.