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<p>Peripheral nerve injury triggers slow axonal regeneration and irreversible muscle atrophy due to the absence of synchronous neuromuscular repair strategies. We present a fully implantable, self-powered Mechano-driven Electro-adaptable Bioelectronic Implant System (MEBIS) enabling coordinated mechanical-electrical stimulation for integrated neuromuscular regeneration. A programmable robotic actuator delivers quantifiable mechanical massage to denervated muscle, enhancing perfusion while deforming a nanogenerator that converts motion into localized electrical cues. These signals stimulate injured nerves, inducing intracellular Ca<sup>2+</sup> elevation and Ca<sup>2+</sup>-dependent signaling, which activates downstream HIF-1α/AMPK pathways to accelerate Schwann cell activity, angiogenesis, and axonal regrowth. This mechano-electro-biochemical cascade couples muscle preservation with nerve regeneration in a closed loop, overcoming depth limitations and output instability of conventional stimulators. Validated in rat and porcine models, MEBIS significantly improves functional recovery, electrophysiology, and histomorphometry without biocompatibility concerns. Our platform establishes a scalable, feedback-controlled paradigm for precision repair and rehabilitation after peripheral nerve injury.</p>

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An implantable mechano-electro cascade platform synchronizes neuro-muscle repair

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月30日

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  • Liping Nan,
  • Wentao Cao,
  • Jiaqi Fang,
  • Pengzhi Shi,
  • Xuehan Jin,
  • Jianguang Wang,
  • Fengshan Jin,
  • Feng Wang,
  • Kaihang Song,
  • Shengfu Liu,
  • Zifei Zhou,
  • Xu Wang,
  • Tianlong Wang,
  • Feng Chen,
  • Junjian Liu,
  • Yun Qian

摘要

Peripheral nerve injury triggers slow axonal regeneration and irreversible muscle atrophy due to the absence of synchronous neuromuscular repair strategies. We present a fully implantable, self-powered Mechano-driven Electro-adaptable Bioelectronic Implant System (MEBIS) enabling coordinated mechanical-electrical stimulation for integrated neuromuscular regeneration. A programmable robotic actuator delivers quantifiable mechanical massage to denervated muscle, enhancing perfusion while deforming a nanogenerator that converts motion into localized electrical cues. These signals stimulate injured nerves, inducing intracellular Ca2+ elevation and Ca2+-dependent signaling, which activates downstream HIF-1α/AMPK pathways to accelerate Schwann cell activity, angiogenesis, and axonal regrowth. This mechano-electro-biochemical cascade couples muscle preservation with nerve regeneration in a closed loop, overcoming depth limitations and output instability of conventional stimulators. Validated in rat and porcine models, MEBIS significantly improves functional recovery, electrophysiology, and histomorphometry without biocompatibility concerns. Our platform establishes a scalable, feedback-controlled paradigm for precision repair and rehabilitation after peripheral nerve injury.