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<p>Fruits are a key feature defining angiosperms, yet how local growth is&#xa0;coordinated during development to generate diverse fruits remains unclear. Here, we demonstrate that the <i>Capsella rubella</i> C2H2-zinc finger transcription factor JAGGED (CrJAG) controls fruit shape determination by promoting both cell division and anisotropic growth. At the molecular level, CrJAG physically interacts with&#xa0;members of the&#xa0;<i>Capsella rubella</i> MULTICOPY SUPPRESSOR OF IRA1 (CrMSI)&#xa0; histone chaperone&#xa0;family, increasing the chromatin accessibility and thereby sustaining the expression of genes involved in fruit morphogenesis. The resulting closed chromatin state in <i>Crjag</i> fruits is characterized by a reduction of the active histone marker (H3K18ac) and an increase of the repressive marker (H3K27me3). Further expression and pharmacological treatment analyses indicate that the developmental defects in <i>Crjag</i> fruits are largely attributable to down-regulation of the key cell-cycle regulator <i>CrAUR2</i>. Collectively, our findings therefore&#xa0;suggest that fine-tuning the cell cycle via epigenetic modification represents an additional, essential layer of regulation critical to organ development and diversification.</p>

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Epigenetic regulation of fruit shape determination by the JAGGED gene in Capsella rubella

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月16日

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  • Tian-Feng Lü,
  • Xiao-Yu Chen,
  • Nicola Trozzi,
  • Wen He,
  • Quan Yuan,
  • Yu Han,
  • Li-Min Lu,
  • Chao-Bin Li,
  • Jie Cheng,
  • Adrien Sicard,
  • Yao Zhang,
  • Ya-Nan Su,
  • Yan-Jun Zan,
  • Michael Lenhard,
  • Hong-Zhi Kong,
  • Mateusz Majda,
  • Lars Østergaard,
  • Yang Dong

摘要

Fruits are a key feature defining angiosperms, yet how local growth is coordinated during development to generate diverse fruits remains unclear. Here, we demonstrate that the Capsella rubella C2H2-zinc finger transcription factor JAGGED (CrJAG) controls fruit shape determination by promoting both cell division and anisotropic growth. At the molecular level, CrJAG physically interacts with members of the Capsella rubella MULTICOPY SUPPRESSOR OF IRA1 (CrMSI)  histone chaperone family, increasing the chromatin accessibility and thereby sustaining the expression of genes involved in fruit morphogenesis. The resulting closed chromatin state in Crjag fruits is characterized by a reduction of the active histone marker (H3K18ac) and an increase of the repressive marker (H3K27me3). Further expression and pharmacological treatment analyses indicate that the developmental defects in Crjag fruits are largely attributable to down-regulation of the key cell-cycle regulator CrAUR2. Collectively, our findings therefore suggest that fine-tuning the cell cycle via epigenetic modification represents an additional, essential layer of regulation critical to organ development and diversification.