<p>Frequency combs have revolutionized communication, metrology, and spectroscopy. Considerable efforts have been devoted to developing integrated combs, primarily leveraging Pockels or Kerr nonlinearities. Here, we demonstrate an alternative frequency comb generated via cavity Floquet engineering. By periodically modulating the cavity resonance frequency through a driven mechanical oscillator, a Floquet cavity with multiple equally spaced frequency components is created. These sidebands exhibit nearest-neighbor coupling and are phase-locked to the external modulation drive. A pump tone interacts with the pre-modulated cavity to generate the output frequency comb, which we implement in an on-chip microwave cavity optomechanical system. This approach operates independently of a pumping threshold and is insensitive to pump detuning. Consequently, it enables comb generation under far-sideband pumping with nanowatt-scale total power consumption, providing an ultra-low-power platform for integrated frequency comb synthesis.</p>