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<p>Cancer-related lymphedema (CRL), the most common type of secondary lymphedema, seriously reduces the life quality of cancer patients. In-depth studies on the pathogenesis of CRL are limited, impeding the development of therapeutic approaches. In this study, an analysis of intercellular heterogeneity reveals a trend towards fibrosis in skin cell subpopulations and identifies the phenomenon of T-cell mesenchymal transition (TcMT). T cells with a mesenchymal phenotype—fibroblast-like (Fib-like) T cells and myofibroblast-like (Myofibro-like) T cells—exhibit a unique fibrotic phenotype and impaired immune function. Furthermore, <i>PDGFRB</i> expression by Fib-like T cells in the affected skin is likely to influence disease severity by regulating TcMT. Additionally, we observe the manifestation of the fibrotic phenotype of T cells in single-cell data from the stromal vascular fraction (SVF) of CRL patients, suggesting that TcMT may be a pathological feature and potential therapeutic target of CRL and providing deep insights into disease pathophysiology.</p>

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T-cell mesenchymal transition represents a potential pathogenic mechanism of female cancer-related lymphedema

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月20日

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  • Liangliang Wang,
  • Junzhe Chen,
  • Miaomiao Wei,
  • Zhiyuan Liu,
  • Yan Zhou,
  • Yuezhong Chen,
  • Yaping Deng,
  • Shune Xiao,
  • Guangchao Xu,
  • Fang Qi,
  • Zairong Wei,
  • Peiru Min,
  • Yixin Zhang,
  • Chengliang Deng

摘要

Cancer-related lymphedema (CRL), the most common type of secondary lymphedema, seriously reduces the life quality of cancer patients. In-depth studies on the pathogenesis of CRL are limited, impeding the development of therapeutic approaches. In this study, an analysis of intercellular heterogeneity reveals a trend towards fibrosis in skin cell subpopulations and identifies the phenomenon of T-cell mesenchymal transition (TcMT). T cells with a mesenchymal phenotype—fibroblast-like (Fib-like) T cells and myofibroblast-like (Myofibro-like) T cells—exhibit a unique fibrotic phenotype and impaired immune function. Furthermore, PDGFRB expression by Fib-like T cells in the affected skin is likely to influence disease severity by regulating TcMT. Additionally, we observe the manifestation of the fibrotic phenotype of T cells in single-cell data from the stromal vascular fraction (SVF) of CRL patients, suggesting that TcMT may be a pathological feature and potential therapeutic target of CRL and providing deep insights into disease pathophysiology.