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<p>Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopic Imaging (HP <sup>13</sup>C-MRSI) has the potential to transform diagnostic radiology thanks to its unique ability to noninvasively detect a broad range of diseases entailing aberrant metabolism. However, clinical adoption has been hindered by the short lifetime of <sup>13</sup>C-hyperpolarization and the resulting need for on-site polarizer near the MR scanner. In this work, we present a solution for long-lived transportable HP molecular contrast agents that uses dissolution Dynamic Nuclear Polarization (dDNP) combined with UV-induced labile radicals. This approach allows centralized pre-polarization and transport under hours-long storage T<sub>1</sub> conditions. We validate this concept through the first across-cities HP <sup>13</sup>C-MRSI experiments in vivo, injecting healthy female rats with both a perfusion/angiography ([1-<sup>13</sup>C]HP001) and a metabolic ([U-<sup>13</sup>C, d<sub>7</sub>]glucose) contrast agent. Our findings advance the feasibility of decentralized, scalable HP MRI workflows, removing the barrier of on-site infrastructure.</p>

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Across-cities transportable 13C hyperpolarization using UV-induced labile radicals

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月15日

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  • Andrea Capozzi,
  • Magnus Karlsson,
  • Yupeng Zhao,
  • Jan Kilund,
  • Esben Søvsø Szocska Hansen,
  • Lotte Bonde Bertelsen,
  • Christoffer Laustsen,
  • Jan Henrik Ardenkjær-Larsen,
  • Mathilde H. Lerche

摘要

Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging (HP 13C-MRSI) has the potential to transform diagnostic radiology thanks to its unique ability to noninvasively detect a broad range of diseases entailing aberrant metabolism. However, clinical adoption has been hindered by the short lifetime of 13C-hyperpolarization and the resulting need for on-site polarizer near the MR scanner. In this work, we present a solution for long-lived transportable HP molecular contrast agents that uses dissolution Dynamic Nuclear Polarization (dDNP) combined with UV-induced labile radicals. This approach allows centralized pre-polarization and transport under hours-long storage T1 conditions. We validate this concept through the first across-cities HP 13C-MRSI experiments in vivo, injecting healthy female rats with both a perfusion/angiography ([1-13C]HP001) and a metabolic ([U-13C, d7]glucose) contrast agent. Our findings advance the feasibility of decentralized, scalable HP MRI workflows, removing the barrier of on-site infrastructure.