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<p>Hemodialysis is the primary life-sustaining therapy for patients with end-stage renal disease (ESRD). Diagnosing and monitoring the health condition of vascular access (VA) for hemodialysis involves the use of ultrasonic imaging and angiography. These infrequent tests cannot, however, identify signs of mild stenosis and sudden onset to facilitate early intervention. Hence, approximately 70% of hemodialysis patients experience VA failure each year, rendering dialysis difficult and posing life-threatening risks. Here, we report wireless, non-invasive thrill sensors incorporating high-resolution accelerometers designed to be conformally placed on VA skin for the continuous monitoring of VA thrill signals, which we tested in multi-platform validation including an in vitro benchtop system, canine models and patients (<i>n</i> = 9). Local measurements of VA thrill intensity via continuous wear demonstrated that a decrease in thrill intensity along the entire VA region is indicative of diminished VA function, while an abnormally heightened thrill intensity at a certain location along the VA indicates localized structural lesions. These thrill sensors may aid the early treatment of VA stenosis upon the transition from subjective thrill palpation to quantitative hemodynamic phenotyping.</p>

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Wireless, non-invasive, high-resolution thrill sensor for continuous vascular access monitoring of hemodialysis patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月15日

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  • Yicong Wang,
  • Jie Wang,
  • Yuqi Tian,
  • Zhiheng Xu,
  • Mengyao Liu,
  • Lin Zhou,
  • Renhua Lv,
  • Yujun Deng,
  • Jinyun Tan,
  • Linfa Peng,
  • Zhongqin Lin

摘要

Hemodialysis is the primary life-sustaining therapy for patients with end-stage renal disease (ESRD). Diagnosing and monitoring the health condition of vascular access (VA) for hemodialysis involves the use of ultrasonic imaging and angiography. These infrequent tests cannot, however, identify signs of mild stenosis and sudden onset to facilitate early intervention. Hence, approximately 70% of hemodialysis patients experience VA failure each year, rendering dialysis difficult and posing life-threatening risks. Here, we report wireless, non-invasive thrill sensors incorporating high-resolution accelerometers designed to be conformally placed on VA skin for the continuous monitoring of VA thrill signals, which we tested in multi-platform validation including an in vitro benchtop system, canine models and patients (n = 9). Local measurements of VA thrill intensity via continuous wear demonstrated that a decrease in thrill intensity along the entire VA region is indicative of diminished VA function, while an abnormally heightened thrill intensity at a certain location along the VA indicates localized structural lesions. These thrill sensors may aid the early treatment of VA stenosis upon the transition from subjective thrill palpation to quantitative hemodynamic phenotyping.