Scholarlink

<p>Fire blight, caused by <i>Erwinia amylovora</i>, severely impacts global apple and pear production. Current control measures rely heavily on conventional antibiotics like streptomycin, oxytetracycline, and kasugamycin, which raise concerns regarding resistance development and environmental impacts. This research introduces RejuAgro A (RAA), an antimicrobial produced by <i>Pseudomonas soli</i> 0617-T307, showing potent activity against <i>E. amylovora</i>, including streptomycin-resistant strains. RAA demonstrates efficacy comparable to streptomycin in field trials, effectively reducing fire blight incidence. Studies on the antimicrobial mechanism reveal that RAA inhibits RNA, DNA, and protein synthesis, distinguishing from that of conventional antibiotics. Furthermore, RAA displays broad-spectrum activity against diverse plant bacterial and fungal pathogens. The RAA biosynthesis gene cluster in <i>P. soli</i> is identified, revealing key genes essential for its production. RAA presents an alternative to traditional antibiotics, potentially enhancing sustainable apple and pear production and addressing antibiotic resistance concerns.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

RejuAgro A as an antimicrobial for fire blight control of pome fruits and beyond

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月11日

查看全文
  • Jian Huang,
  • Ton Nu Bao Vy Huyen,
  • Xiangyang Liu,
  • Shreyashi Mitra,
  • Manda Yu,
  • Quan Zeng,
  • George W. Sundin,
  • Kerik D. Cox,
  • Helga Förster,
  • James E. Adaskaveg,
  • Chih-Horng Kuo,
  • Xiaochen Yuan,
  • Russell L. Cuhel,
  • Ching-Hong Yang

摘要

Fire blight, caused by Erwinia amylovora, severely impacts global apple and pear production. Current control measures rely heavily on conventional antibiotics like streptomycin, oxytetracycline, and kasugamycin, which raise concerns regarding resistance development and environmental impacts. This research introduces RejuAgro A (RAA), an antimicrobial produced by Pseudomonas soli 0617-T307, showing potent activity against E. amylovora, including streptomycin-resistant strains. RAA demonstrates efficacy comparable to streptomycin in field trials, effectively reducing fire blight incidence. Studies on the antimicrobial mechanism reveal that RAA inhibits RNA, DNA, and protein synthesis, distinguishing from that of conventional antibiotics. Furthermore, RAA displays broad-spectrum activity against diverse plant bacterial and fungal pathogens. The RAA biosynthesis gene cluster in P. soli is identified, revealing key genes essential for its production. RAA presents an alternative to traditional antibiotics, potentially enhancing sustainable apple and pear production and addressing antibiotic resistance concerns.