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<p>Serotonin (5-hydroxytryptamine; 5HT) has long been considered anti-aggressive, but the mechanisms by which 5HT regulates downstream circuits to control aggression remain unclear. Combining fiber photometry, optogenetics, and miniaturized microscope recordings in double-transgenic male mice, we find that 5HT levels ramp up in the nucleus accumbens during aggression, inhibiting a subset of D1 medium spiny neurons to suppress attacks. Our results reveal a novel 5HT-mediated neuromodulatory mechanism for limiting aggressive behavior.</p>

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Serotonin modulates nucleus accumbens circuits to suppress aggression in mice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月14日

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  • Zihui Zhang,
  • Gavin C. Touponse,
  • Pia J. Alderman,
  • Teema Yassine,
  • Matthew B. Pomrenze,
  • Troy W. Harris,
  • Amei N. Shank,
  • Robert C. Malenka,
  • Neir Eshel

摘要

Serotonin (5-hydroxytryptamine; 5HT) has long been considered anti-aggressive, but the mechanisms by which 5HT regulates downstream circuits to control aggression remain unclear. Combining fiber photometry, optogenetics, and miniaturized microscope recordings in double-transgenic male mice, we find that 5HT levels ramp up in the nucleus accumbens during aggression, inhibiting a subset of D1 medium spiny neurons to suppress attacks. Our results reveal a novel 5HT-mediated neuromodulatory mechanism for limiting aggressive behavior.