Scholarlink

<p>As the prevalence of cardiovascular risk factors in children continues to rise globally, identifying modifiable lifestyle factors becomes increasingly important for early prevention. Here, using data from a large-scale cohort (2021–2024) involving 7459 Chinese children from three provinces, we examine the association between eating timing patterns and multiple cardiovascular parameters. Participants are classified into three eating patterns: extended eating window (duration more than 12.5 hours), late eating window (duration 12.5 hours or less with last meal after 20:00), and early eating window (duration 12.5 hours or less with last meal at or before 20:00). Early eating window is associated with a 26% lower risk of elevated blood pressure (odds ratio: 0.74, 95% confidence interval: 0.65–0.84, <i>p</i> &lt; 0.001) compared to extended eating window. We conduct a nested case-control study (<i>n</i> = 51) with comprehensive lipidomic and proteomic analyses. Proteomics identifies 83 differentially expressed proteins, with enrichment in cardiac muscle contraction and lipid metabolism pathways. Mediation analysis demonstrates that triacylglycerols mediate 64.8% of the effect between eating patterns and blood pressure. Our findings suggest associations between early eating windows and protective cardiovascular parameters in children, potentially mediated through lipid metabolism pathways.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Multiomics insights into eating time patterns and cardiovascular risk among Chinese children

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月21日

查看全文
  • Qin Liu,
  • Jingyu Chen,
  • Xizhou An,
  • Lanling Chen,
  • Bo Bai,
  • Lijing Chen,
  • Daochao Huang,
  • Jun Ma,
  • Lun Xiao,
  • Shuanggui Yuan,
  • Jianxin Li,
  • Xiaohua Liang

摘要

As the prevalence of cardiovascular risk factors in children continues to rise globally, identifying modifiable lifestyle factors becomes increasingly important for early prevention. Here, using data from a large-scale cohort (2021–2024) involving 7459 Chinese children from three provinces, we examine the association between eating timing patterns and multiple cardiovascular parameters. Participants are classified into three eating patterns: extended eating window (duration more than 12.5 hours), late eating window (duration 12.5 hours or less with last meal after 20:00), and early eating window (duration 12.5 hours or less with last meal at or before 20:00). Early eating window is associated with a 26% lower risk of elevated blood pressure (odds ratio: 0.74, 95% confidence interval: 0.65–0.84, p < 0.001) compared to extended eating window. We conduct a nested case-control study (n = 51) with comprehensive lipidomic and proteomic analyses. Proteomics identifies 83 differentially expressed proteins, with enrichment in cardiac muscle contraction and lipid metabolism pathways. Mediation analysis demonstrates that triacylglycerols mediate 64.8% of the effect between eating patterns and blood pressure. Our findings suggest associations between early eating windows and protective cardiovascular parameters in children, potentially mediated through lipid metabolism pathways.