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<p>Oats have various positive effects on human health, but the underlying mechanisms are not fully understood. To identify oat-microbiome-host interactions contributing to metabolic improvements, we conducted two randomized controlled dietary interventions in parallel-design in individuals with metabolic syndrome, comparing a short-term, high-dose and a six-week, moderate oat intake with respective controls (DRKS00022169). Both oat diets lead to an increase in plasma ferulic acid (0.64 [0.26, 1.02], <i>P</i> = 0.002; 0.55 [0.21, 0.89], <i>P</i> = 0.003), while the high-dose oat-diet also increased dihydroferulic acid (1.23 [0.44, 2.01], <i>P</i> = 0.003). Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats, which might be of relevance since short-term, high-dose oat-diet is a suitable approach to alleviate obesity-related lipid disorders.</p>

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Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月14日

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  • Linda Klümpen,
  • Aakash Mantri,
  • Maren Philipps,
  • Waldemar Seel,
  • Laura Schlautmann,
  • Mohamed H. Yaghmour,
  • Verena Wiemann,
  • Birgit Stoffel-Wagner,
  • Martin Coenen,
  • Leonie Weinhold,
  • Jan Hasenauer,
  • Thomas Fließwasser,
  • Sven Burgdorf,
  • Christoph Thiele,
  • Peter Stehle,
  • Marie-Christine Simon

摘要

Oats have various positive effects on human health, but the underlying mechanisms are not fully understood. To identify oat-microbiome-host interactions contributing to metabolic improvements, we conducted two randomized controlled dietary interventions in parallel-design in individuals with metabolic syndrome, comparing a short-term, high-dose and a six-week, moderate oat intake with respective controls (DRKS00022169). Both oat diets lead to an increase in plasma ferulic acid (0.64 [0.26, 1.02], P = 0.002; 0.55 [0.21, 0.89], P = 0.003), while the high-dose oat-diet also increased dihydroferulic acid (1.23 [0.44, 2.01], P = 0.003). Here we show that microbial phenolic metabolites are driving factors for the cholesterol-lowering effect of oats, which might be of relevance since short-term, high-dose oat-diet is a suitable approach to alleviate obesity-related lipid disorders.