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<p>Cortical implants are a proven clinical neurotechnology with the potential to transform our understanding of cognitive processes. These processes rely on complex neuronal networks that are difficult to selectively probe or stimulate. Optogenetics offers cell-type specificity, but achieving the density and coverage required for chronic, high-resolution modulation remains a challenge. We fabricated 100-element <i>μ</i>LED arrays (200 <i>μ</i>m pixel pitch, 2&#xa0;× 2 mm<sup>2</sup> footprint) coupled into chronically implantable systems for optogenetic stimulation of the mouse cortex. The <i>μ</i>LEDs remain stable for over 300 hours continuous operation time in vivo, allowing for months-long chronic experiments. Simultaneous electrophysiology recordings confirmed robust neuronal responses at low <i>μ</i>LED drive currents (&lt;&#xa0;5 mA), minimising thermal effects. Here we show that our device can be chronically implanted in freely-behaving mice and drive behavioural outcomes from spatiotemporal, patterned, optogenetic stimulation of auditory cortical circuits.</p>

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Chronically implantable μLED arrays for optogenetic cortical surface stimulation in mice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月14日

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  • Ryan Greer,
  • Antonin Verdier,
  • Emma Butt,
  • Yunzhou Cheng,
  • Ella Callas,
  • Niall McAlinden,
  • Alicia Aniorte,
  • Eya Mabrouk Kakaouia,
  • Magdalena Pereyra,
  • Martin D. Dawson,
  • Brice Bathellier,
  • Keith Mathieson

摘要

Cortical implants are a proven clinical neurotechnology with the potential to transform our understanding of cognitive processes. These processes rely on complex neuronal networks that are difficult to selectively probe or stimulate. Optogenetics offers cell-type specificity, but achieving the density and coverage required for chronic, high-resolution modulation remains a challenge. We fabricated 100-element μLED arrays (200 μm pixel pitch, 2 × 2 mm2 footprint) coupled into chronically implantable systems for optogenetic stimulation of the mouse cortex. The μLEDs remain stable for over 300 hours continuous operation time in vivo, allowing for months-long chronic experiments. Simultaneous electrophysiology recordings confirmed robust neuronal responses at low μLED drive currents (< 5 mA), minimising thermal effects. Here we show that our device can be chronically implanted in freely-behaving mice and drive behavioural outcomes from spatiotemporal, patterned, optogenetic stimulation of auditory cortical circuits.