Scholarlink

<p>Dopaminergic signaling shapes large-scale brain network architecture, constraining neural communication along a principal gradient that spans unimodal sensorimotor to transmodal association cortices. While more differentiated gradients are typically linked to enhanced cognition, it remains unclear whether dopamine-enhancing psychostimulants, such as methylphenidate (MP), amplify or compress this functional hierarchy to support attention. Across two double-blind, placebo-controlled studies in healthy adults (n = 38 and n = 20), we combined 60 mg oral MP with PET and fMRI to assess striatal dopamine function and cortical organization. MP consistently compressed the principal gradient, reducing segregation between sensory and association areas. The degree of compression predicted individual variation in striatal D1 and D2 receptor availability. MP-induced gradient compression in inferior parietal cortex tracked attention improvements. Critically, we validated key findings in a large, independent cohort from the Adolescent Brain Cognitive Development (ABCD) study (n = 4,958). These results highlight a dopamine-sensitive mechanism linking cortical functional reorganization with cognitive performance.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月13日

查看全文
  • Dardo Tomasi,
  • Peter Manza,
  • Şükrü Barış Demiral,
  • Weizheng Yan,
  • Kylee B. Miller,
  • Faith Veenker,
  • Joshua Zhao,
  • Christina Lildharrie,
  • Michele-Vera Yonga,
  • Sarah Abey,
  • Michaelene VanDine,
  • Gene-Jack Wang,
  • Nora D. Volkow

摘要

Dopaminergic signaling shapes large-scale brain network architecture, constraining neural communication along a principal gradient that spans unimodal sensorimotor to transmodal association cortices. While more differentiated gradients are typically linked to enhanced cognition, it remains unclear whether dopamine-enhancing psychostimulants, such as methylphenidate (MP), amplify or compress this functional hierarchy to support attention. Across two double-blind, placebo-controlled studies in healthy adults (n = 38 and n = 20), we combined 60 mg oral MP with PET and fMRI to assess striatal dopamine function and cortical organization. MP consistently compressed the principal gradient, reducing segregation between sensory and association areas. The degree of compression predicted individual variation in striatal D1 and D2 receptor availability. MP-induced gradient compression in inferior parietal cortex tracked attention improvements. Critically, we validated key findings in a large, independent cohort from the Adolescent Brain Cognitive Development (ABCD) study (n = 4,958). These results highlight a dopamine-sensitive mechanism linking cortical functional reorganization with cognitive performance.