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<p>Some of the most dramatic examples of neuroplasticity in the human brain follow congenital sensory deprivation, yet the plasticity mechanisms producing this large-scale cortical remapping remain poorly understood. Congenital malformation of the upper-limb provides a unique temporal dissociation of developmental plasticity mechanisms: While sensory deprivation from the absent hand is triggered before birth, compensatory motor behaviours develop gradually throughout childhood. Using paediatric neuroimaging and semi-ecological behavioural analysis in children (5-7 years old) and adults (&gt;25 years old) with unilateral upper-limb congenital limb difference, we studied deprivation- and use-dependent plasticity in the deprived primary somatosensory cortex and beyond. We reveal that global remapping, encompassing the entire sensory homunculus, is established early and maintained in adulthood. Modelling indicates that deprivation-driven homeostatic plasticity can account for this global remapping. Hebbian-based compensatory learning further contributes to the magnitude of inter-individual differences observed at both childhood and adulthood. Our findings emphasise the early establishment and stability of cortical maps, despite extensive daily-life behavioural adaptation.</p>

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Global remapping of the sensory homunculus emerges early in childhood development

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月24日

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  • Raffaele Tucciarelli,
  • Laura Bird,
  • Zdenek Straka,
  • Maggie Szymanska,
  • Mathew Kollamkulam,
  • Harshal Arun Sonar,
  • Jamie Paik,
  • Danielle Clode,
  • Matej Hoffmann,
  • Dorothy Cowie,
  • Tamar R. Makin

摘要

Some of the most dramatic examples of neuroplasticity in the human brain follow congenital sensory deprivation, yet the plasticity mechanisms producing this large-scale cortical remapping remain poorly understood. Congenital malformation of the upper-limb provides a unique temporal dissociation of developmental plasticity mechanisms: While sensory deprivation from the absent hand is triggered before birth, compensatory motor behaviours develop gradually throughout childhood. Using paediatric neuroimaging and semi-ecological behavioural analysis in children (5-7 years old) and adults (>25 years old) with unilateral upper-limb congenital limb difference, we studied deprivation- and use-dependent plasticity in the deprived primary somatosensory cortex and beyond. We reveal that global remapping, encompassing the entire sensory homunculus, is established early and maintained in adulthood. Modelling indicates that deprivation-driven homeostatic plasticity can account for this global remapping. Hebbian-based compensatory learning further contributes to the magnitude of inter-individual differences observed at both childhood and adulthood. Our findings emphasise the early establishment and stability of cortical maps, despite extensive daily-life behavioural adaptation.