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<p>Cardiac amyloidosis (CA) occurs when misfolded proteins deposit as fibrils in the extracellular space of the heart. The fibrillogenic properties of apolipoprotein A-IV (ApoAIV) have been histologically observed and associated with CA pathogenesis. We report the structure of an ApoAIV amyloid from a patient’s heart, which coexist amongst transthyretin (TTR) amyloids. These cases of undetected mixed CA highlight the importance of developing broad-spectrum anti-amyloid treatments to improve outcomes in patients.</p>

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Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月20日

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  • Shintaro Aibara,
  • Astrid Kassner,
  • Edmond Wong,
  • Karin Klingel,
  • Monika Papworth,
  • Magnus Althage,
  • Qing-Dong Wang,
  • Claudia Correia,
  • Hendrik Milting,
  • Taiana Maia de Oliveira

摘要

Cardiac amyloidosis (CA) occurs when misfolded proteins deposit as fibrils in the extracellular space of the heart. The fibrillogenic properties of apolipoprotein A-IV (ApoAIV) have been histologically observed and associated with CA pathogenesis. We report the structure of an ApoAIV amyloid from a patient’s heart, which coexist amongst transthyretin (TTR) amyloids. These cases of undetected mixed CA highlight the importance of developing broad-spectrum anti-amyloid treatments to improve outcomes in patients.