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<p>Monitoring wound protein biomarkers, especially inflammation-related proteins, is essential to assess wound progression and guide treatment. However, high-fidelity wound biosensing is challenging because of current biosensors’ limitations in detecting low-abundance proteins and their vulnerabilities to mechanical deformation, biofouling, and performance degradation. Here, we introduce a soft bioelectronics embedded with Self-Confined Tetrahedral DNA circuit (SCTD) for wound monitoring. In SCTD, proteins in wound exudate trigger DNA self-circulation amplification confined in the hydrophilic area, decreasing detection limits by an order of magnitude. The tetrahedral DNA structure ensures excellent mechanical stability (within 3% variation after 1000 bending cycles), prolonged stability (within 8% signal attenuation over 4 weeks), and reduced biofouling (over 50% BSA adhesion reduction). Coupled with wireless readout, this platform simultaneously monitors multiple wound healing-related proteins (TNF-α, IL-6, TGF-β1, and VEGF) and biophysical parameters. The wireless platform demonstrates accurate <i>in</i>-<i>situ</i> monitoring of both non-infected and infected wounds on diabetic male mice without hindering the healing process, offering quantitative and comprehensive evaluation to guide treatment.</p>

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Soft bioelectronics embedded with self-confined tetrahedral DNA circuit for high-fidelity chronic wound monitoring

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月7日

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  • Xiao Zhao,
  • Jiahao Huang,
  • Juncheng Zhang,
  • Bowen Yang,
  • Zijuan Hu,
  • Ting Li,
  • Xiang Ma,
  • Chunyan Jiang,
  • Haochen Zou,
  • Songrui Liu,
  • Qiusui He,
  • Lixing Weng,
  • Ting Wang,
  • Lianhui Wang

摘要

Monitoring wound protein biomarkers, especially inflammation-related proteins, is essential to assess wound progression and guide treatment. However, high-fidelity wound biosensing is challenging because of current biosensors’ limitations in detecting low-abundance proteins and their vulnerabilities to mechanical deformation, biofouling, and performance degradation. Here, we introduce a soft bioelectronics embedded with Self-Confined Tetrahedral DNA circuit (SCTD) for wound monitoring. In SCTD, proteins in wound exudate trigger DNA self-circulation amplification confined in the hydrophilic area, decreasing detection limits by an order of magnitude. The tetrahedral DNA structure ensures excellent mechanical stability (within 3% variation after 1000 bending cycles), prolonged stability (within 8% signal attenuation over 4 weeks), and reduced biofouling (over 50% BSA adhesion reduction). Coupled with wireless readout, this platform simultaneously monitors multiple wound healing-related proteins (TNF-α, IL-6, TGF-β1, and VEGF) and biophysical parameters. The wireless platform demonstrates accurate in-situ monitoring of both non-infected and infected wounds on diabetic male mice without hindering the healing process, offering quantitative and comprehensive evaluation to guide treatment.