Scholarlink

<p>Piezoelectric stimulation regulates cellular metabolism and enhances bone repair. However, the overproduction of reactive oxygen species (ROS) and hypoxia-induced oxidative stress reduce the efficacy of electrical stimulation and hinder regeneration. Here, a platinum-decorated graphdiyne oxide (GDYO@Pt) multifunctional piezoelectric semiconductor was engineered to eliminate ROS and oxygen self-supply while enabling electrical stimulation. In this system, the interface dipole drives a built-in electric field, triggering charge redistribution in GDYO and breaking symmetry to amplify piezoelectricity. Ultrasound-triggered polarized charges at the Schottky junction lower the barrier and promote GDYO→Pt electron transfer for hydrogen production, where the generated H<sub>2</sub> neutralizes cytotoxic •OH radicals, while the holes/nanozyme drive H<sub>2</sub>O<sub>2</sub> → O<sub>2</sub> conversion, synergistically alleviating oxidative stress. In vitro and vivo studies demonstrate that ultrasound-activated GDYO@Pt accelerates cranial defect repair via osteogenesis, angiogenesis, and immunomodulation. This work shows piezoelectric-catalytic synergistic bone regeneration, where the GDYO@Pt heterointerface integrates energy conversion with biological regulation through an engineered asymmetric structure.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Schottky engineering of GDYO@Pt to boost piezoelectric and oxidative stress modulation for accelerated cranial regeneration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月26日

查看全文
  • Kang Song,
  • Xuezheng Geng,
  • Huan Yin,
  • Yanzhu Shi,
  • Jiawei Wang,
  • Jiayu Yu,
  • Mateng Bai,
  • Lizhen Wang,
  • Yurui Xue,
  • Chunli Song,
  • Yubo Fan

摘要

Piezoelectric stimulation regulates cellular metabolism and enhances bone repair. However, the overproduction of reactive oxygen species (ROS) and hypoxia-induced oxidative stress reduce the efficacy of electrical stimulation and hinder regeneration. Here, a platinum-decorated graphdiyne oxide (GDYO@Pt) multifunctional piezoelectric semiconductor was engineered to eliminate ROS and oxygen self-supply while enabling electrical stimulation. In this system, the interface dipole drives a built-in electric field, triggering charge redistribution in GDYO and breaking symmetry to amplify piezoelectricity. Ultrasound-triggered polarized charges at the Schottky junction lower the barrier and promote GDYO→Pt electron transfer for hydrogen production, where the generated H2 neutralizes cytotoxic •OH radicals, while the holes/nanozyme drive H2O2 → O2 conversion, synergistically alleviating oxidative stress. In vitro and vivo studies demonstrate that ultrasound-activated GDYO@Pt accelerates cranial defect repair via osteogenesis, angiogenesis, and immunomodulation. This work shows piezoelectric-catalytic synergistic bone regeneration, where the GDYO@Pt heterointerface integrates energy conversion with biological regulation through an engineered asymmetric structure.