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<p>Physical exercise is an effective therapy for improving stroke recovery. However, the exact underlying molecular mechanisms of exercise-enhanced neuronal repair remain unclear. As exercise affects the immune system in healthy individuals, and the immune system in turn influences recovery after stroke, we hypothesized that immune mechanisms play a role in exercise-induced neurological recovery. Using a model of ischemic stroke in adult male mice, we here show that the presence of regulatory T cells (Treg) within the ischemic brain is a prerequisite for exercise-enhanced functional and structural recovery. Treg prevent excessive and sustained hyperexcitability of periinfarct neurons via IL-10 signaling. This reduced hyperexcitability precedes alterations in neuronal connectivity, which underlie functional improvement. Together, we delineate the interaction of exercise-therapy, the immune system and functional recovery after ischemic stroke. Our findings can have translational relevance for further development of immune-targeted therapies.</p>

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Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月8日

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  • A. Schmidt-Pogoda,
  • T. Ruck,
  • JK Strecker,
  • M. Hoppen,
  • L. Fazio,
  • L. Vinnenberg,
  • B. Maus,
  • L. Wachsmuth,
  • M. Cerina,
  • K. Diederich,
  • S. Lichtenberg,
  • H. Abberger,
  • LAL Haertel,
  • D. Schafflick,
  • G. Meyer zu Hörste,
  • AM Herrmann,
  • P. Hundehege,
  • V. Narayanan,
  • C. Nelke,
  • K. Kruithoff,
  • J. Bosbach,
  • E. Vicari,
  • T. Ramcke,
  • C. Beuker,
  • E. Hadaschik,
  • T. Budde,
  • C. Faber,
  • H. Wiendl,
  • W. Hansen,
  • SG Meuth,
  • J. Minnerup

摘要

Physical exercise is an effective therapy for improving stroke recovery. However, the exact underlying molecular mechanisms of exercise-enhanced neuronal repair remain unclear. As exercise affects the immune system in healthy individuals, and the immune system in turn influences recovery after stroke, we hypothesized that immune mechanisms play a role in exercise-induced neurological recovery. Using a model of ischemic stroke in adult male mice, we here show that the presence of regulatory T cells (Treg) within the ischemic brain is a prerequisite for exercise-enhanced functional and structural recovery. Treg prevent excessive and sustained hyperexcitability of periinfarct neurons via IL-10 signaling. This reduced hyperexcitability precedes alterations in neuronal connectivity, which underlie functional improvement. Together, we delineate the interaction of exercise-therapy, the immune system and functional recovery after ischemic stroke. Our findings can have translational relevance for further development of immune-targeted therapies.