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<p>Hospitalisation and routine antibiotic treatment are recommended for children with complicated severe acute malnutrition (SAM) but this may exacerbate antimicrobial resistance. Here, we investigate carriage of Gram-negative bacteria in children under five years of age receiving treatment for SAM in Niger, comparing the frequency of colonisation with bacteria carrying resistance genes at admission, during hospital stay and at discharge. <i>E. coli</i> isolates carrying a <i>bla</i><sub>NDM-5</sub> gene were selected for whole-genome sequencing. Rectal colonisation with bacteria carrying ß-lactamase genes is high, with 76% (n = 1042/1371) of children harbouring bacteria carrying a <i>bla</i><sub>CTXM-1</sub>-group gene and 25% (n = 338/1371) carrying a <i>bla</i><sub>NDM-5</sub> gene. Over two-thirds of children who did not carry bacteria with a carbapenemase gene at admission are colonised with bacteria carrying a carbapenemase gene at discharge (n = 503/729, 69%). <i>E. coli</i> ST167 carrying <i>bla</i><sub>NDM-5</sub> gene is recovered from 11% (n = 144/1371) of children. Here we highlight infection control and bacterial AMR transmission concerns amongst a vulnerable population in need of medical treatment.</p>

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Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月1日

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  • Kirsty Sands,
  • Aditya Kumar Lankapalli,
  • Giulia Lai,
  • Brekhna Hassan,
  • Edward AR Portal,
  • Jordan AT Mathias,
  • Ian Boostrom,
  • Mei Li,
  • Kate Cook,
  • Shonnette Premchand-Branker,
  • Lim S. Jones,
  • Nathan Sayinzonga-Makombe,
  • Sheila Isanaka,
  • Rupa Kanapathipillai,
  • Christopher Mambula,
  • Isabelle Mouniaman,
  • Céline Langendorf,
  • Timothy R. Walsh,
  • Owen B. Spiller

摘要

Hospitalisation and routine antibiotic treatment are recommended for children with complicated severe acute malnutrition (SAM) but this may exacerbate antimicrobial resistance. Here, we investigate carriage of Gram-negative bacteria in children under five years of age receiving treatment for SAM in Niger, comparing the frequency of colonisation with bacteria carrying resistance genes at admission, during hospital stay and at discharge. E. coli isolates carrying a blaNDM-5 gene were selected for whole-genome sequencing. Rectal colonisation with bacteria carrying ß-lactamase genes is high, with 76% (n = 1042/1371) of children harbouring bacteria carrying a blaCTXM-1-group gene and 25% (n = 338/1371) carrying a blaNDM-5 gene. Over two-thirds of children who did not carry bacteria with a carbapenemase gene at admission are colonised with bacteria carrying a carbapenemase gene at discharge (n = 503/729, 69%). E. coli ST167 carrying blaNDM-5 gene is recovered from 11% (n = 144/1371) of children. Here we highlight infection control and bacterial AMR transmission concerns amongst a vulnerable population in need of medical treatment.