Scholarlink

<p>Molecular tracing of extremely low amounts of biofluids is vital for precise diagnostic analysis. Although optical nanosensors for real-time spatiotemporal molecular tracing exist, integrating them into simple devices that capture low-volume fluids on rough, dynamic surfaces remains challenging. We present a bioinspired 3D microstructured patch monolithically integrated with optical nanosensors (3D MIN) for real-time, multivariate molecular tracing of ultralow-volume fluids. Inspired by tree frog toe pads, the 3D MIN features soft, hexagonally aligned pillars and microchannels for conformal adhesion and targeted fluid management. Embedding near-infrared fluorescent single-walled carbon nanotube nanosensors in a hydrogel enables simultaneous fluid capture and detection. Softening the elastomer microarchitecture and optimizing water management promote stable adhesion on wet biosurfaces, allowing rapid collection of ultralow-volume fluids (~0.1 µL/min·cm²). We demonstrate real-time, remote sweat analysis with ≥75 nL volumes collected in 45 s, without exercise or iontophoresis, showcasing high biocompatibility and efficient spatiotemporal molecular tracing.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Spatiotemporal molecular tracing of ultralow-volume biofluids via a soft skin-adaptive optical monolithic patch sensor

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月5日

查看全文
  • Yeon Soo Lee,
  • Seyoung Shin,
  • Gyun Ro Kang,
  • Siyeon Lee,
  • Da Wan Kim,
  • Seongcheol Park,
  • Youngwook Cho,
  • Dohyun Lim,
  • Seung Hwan Jeon,
  • Soo-Yeon Cho,
  • Changhyun Pang

摘要

Molecular tracing of extremely low amounts of biofluids is vital for precise diagnostic analysis. Although optical nanosensors for real-time spatiotemporal molecular tracing exist, integrating them into simple devices that capture low-volume fluids on rough, dynamic surfaces remains challenging. We present a bioinspired 3D microstructured patch monolithically integrated with optical nanosensors (3D MIN) for real-time, multivariate molecular tracing of ultralow-volume fluids. Inspired by tree frog toe pads, the 3D MIN features soft, hexagonally aligned pillars and microchannels for conformal adhesion and targeted fluid management. Embedding near-infrared fluorescent single-walled carbon nanotube nanosensors in a hydrogel enables simultaneous fluid capture and detection. Softening the elastomer microarchitecture and optimizing water management promote stable adhesion on wet biosurfaces, allowing rapid collection of ultralow-volume fluids (~0.1 µL/min·cm²). We demonstrate real-time, remote sweat analysis with ≥75 nL volumes collected in 45 s, without exercise or iontophoresis, showcasing high biocompatibility and efficient spatiotemporal molecular tracing.