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<p>Malignant pleural effusion (MPE), persistently generated by thorax tumor cells at the&#xa0;advanced stage, remains a major challenge for cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system by doping ytterbium in metal-organic framework (O<sub>3</sub>P@LPYU), which can be triggered by physiological intrapleural pressure during breath. Under the gently alterative pressure, the piezoelectric nanoparticles with notable peroxidase-like activity effectively produce a burst of reactive oxygen species and induce immunogenic cell death by catalysis of carried ozone as well as peroxide in interstitial fluid. A clear and sustained biodistribution is observed in thorax effusion and tumors upon intrapleural administration of particle. Remarkably, due to the abundant substrates in oxygen-rich environment of pleural cavity, O<sub>3</sub>P@LPYU particle provides a potent reduction of MPE volume and durable inhibition of tumor growth in thorax. Our work not only develops a bio-responsive piezoelectric nano-system, but also provides a strategy for persistent suppression of MPE in clinics.</p>

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Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月3日

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  • Zihan Xu,
  • Xiujing He,
  • Yu Gui,
  • Lingkai Tang,
  • Yuxin Zhao,
  • Linlin Song,
  • Tianyue Xu,
  • Meixu Chen,
  • Yujie Zhao,
  • Peixin Du,
  • Xin Wang,
  • Siyi Chen,
  • Yong Luo,
  • Feng Luo,
  • Huan Meng,
  • Jianping Hu,
  • Wei Zhuo,
  • Jing Jing,
  • Hubing Shi

摘要

Malignant pleural effusion (MPE), persistently generated by thorax tumor cells at the advanced stage, remains a major challenge for cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system by doping ytterbium in metal-organic framework (O3P@LPYU), which can be triggered by physiological intrapleural pressure during breath. Under the gently alterative pressure, the piezoelectric nanoparticles with notable peroxidase-like activity effectively produce a burst of reactive oxygen species and induce immunogenic cell death by catalysis of carried ozone as well as peroxide in interstitial fluid. A clear and sustained biodistribution is observed in thorax effusion and tumors upon intrapleural administration of particle. Remarkably, due to the abundant substrates in oxygen-rich environment of pleural cavity, O3P@LPYU particle provides a potent reduction of MPE volume and durable inhibition of tumor growth in thorax. Our work not only develops a bio-responsive piezoelectric nano-system, but also provides a strategy for persistent suppression of MPE in clinics.