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<p>In photosynthetic organisms, light acts as an environmental signal to control their development and physiology, as well as energy source to drive the conversion of CO<sub>2</sub> into carbohydrates used for growth or storage. The main storage carbohydrate in green algae is starch, which accumulates during the day and is broken down at night to meet cellular energy demands. The signaling role of light quality in the regulation of starch accumulation remains unexplored. Here, we identify PHOTOTROPIN-MEDIATED SIGNALING KINASE 1 (PMSK1) as a key regulator of starch metabolism in <i>Chlamydomonas reinhardtii</i>. In its phosphorylated form (PMSK1-P), it activates GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAP1), promoting starch biosynthesis. We show that blue light, perceived by PHOTOTROPIN, induces PMSK1 dephosphorylation that in turn represses GAP1 mRNA levels and reduces starch accumulation. These findings reveal a previously uncharacterized blue light-mediated signaling pathway that advances our understanding of photoreceptor-controlled carbon metabolism in microalgae.</p>

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Phototropin connects blue light perception to starch metabolism in green algae

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月15日

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  • Yizhong Yuan,
  • Anthony A. Iannetta,
  • Minjae Kim,
  • Patric W. Sadecki,
  • Marius Arend,
  • Angeliki Tsichla,
  • M. Águila Ruiz-Sola,
  • Georgios Kepesidis,
  • Denis Falconet,
  • Emmanuel Thevenon,
  • Marianne Tardif,
  • Sabine Brugière,
  • Yohann Couté,
  • Jean Philippe Kleman,
  • Irina Sizova,
  • Marion Schilling,
  • Juliette Jouhet,
  • Peter Hegemann,
  • Yonghua Li-Beisson,
  • Zoran Nikoloski,
  • Olivier Bastien,
  • Leslie M. Hicks,
  • Dimitris Petroutsos

摘要

In photosynthetic organisms, light acts as an environmental signal to control their development and physiology, as well as energy source to drive the conversion of CO2 into carbohydrates used for growth or storage. The main storage carbohydrate in green algae is starch, which accumulates during the day and is broken down at night to meet cellular energy demands. The signaling role of light quality in the regulation of starch accumulation remains unexplored. Here, we identify PHOTOTROPIN-MEDIATED SIGNALING KINASE 1 (PMSK1) as a key regulator of starch metabolism in Chlamydomonas reinhardtii. In its phosphorylated form (PMSK1-P), it activates GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAP1), promoting starch biosynthesis. We show that blue light, perceived by PHOTOTROPIN, induces PMSK1 dephosphorylation that in turn represses GAP1 mRNA levels and reduces starch accumulation. These findings reveal a previously uncharacterized blue light-mediated signaling pathway that advances our understanding of photoreceptor-controlled carbon metabolism in microalgae.