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<p>Multi-modal large language models (MLLMs) have transformed the landscape of modern healthcare, with automated radiology report generation (RRG) emerging as a cutting-edge application. While 2D MLLM-based RRG has been well established, its utility for 3D medical images remains largely unexplored. In this regard, we curate the 3D-BrainCT dataset (18,885 text-scan pairs) and develop BrainGPT, a clinically visual instruction-tuned (CVIT) model designed for 3D CT RRG. While we notice that the traditional LLM metrics failed to gauge the diagnostic quality of the RRG, we propose feature-oriented radiology task evaluation (FORTE), an evaluation scheme that captures the clinical essence of the generated reports. Here we show that BrainGPT achieves an average FORTE F1-score of 0.71 (degree = 0.661; landmark = 0.706; feature = 0.693, and impression = 0.779) and 74% of BrainGPT-generated reports were indistinguishable from human-written ground truth in a <i>Turing</i>-like test. Together, our work establishes a comprehensive framework encompassing dataset curation, anatomy-aware model fine-tuning, and the development of robust evaluation metrics for the RRG. By sharing our experience in 3D MLLM-based RRG, we aim to accelerate the expedition in human-machine collaboration for next-generation healthcare.</p>

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Towards a holistic framework for multimodal LLM in 3D brain CT radiology report generation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月6日

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  • Cheng-Yi Li,
  • Kao-Jung Chang,
  • Cheng-Fu Yang,
  • Hsin-Yu Wu,
  • Wenting Chen,
  • Hritik Bansal,
  • Ling Chen,
  • Yi-Ping Yang,
  • Yu-Chun Chen,
  • Shih-Pin Chen,
  • Shih-Jen Chen,
  • Jiing-Feng Lirng,
  • Kai-Wei Chang,
  • Shih-Hwa Chiou

摘要

Multi-modal large language models (MLLMs) have transformed the landscape of modern healthcare, with automated radiology report generation (RRG) emerging as a cutting-edge application. While 2D MLLM-based RRG has been well established, its utility for 3D medical images remains largely unexplored. In this regard, we curate the 3D-BrainCT dataset (18,885 text-scan pairs) and develop BrainGPT, a clinically visual instruction-tuned (CVIT) model designed for 3D CT RRG. While we notice that the traditional LLM metrics failed to gauge the diagnostic quality of the RRG, we propose feature-oriented radiology task evaluation (FORTE), an evaluation scheme that captures the clinical essence of the generated reports. Here we show that BrainGPT achieves an average FORTE F1-score of 0.71 (degree = 0.661; landmark = 0.706; feature = 0.693, and impression = 0.779) and 74% of BrainGPT-generated reports were indistinguishable from human-written ground truth in a Turing-like test. Together, our work establishes a comprehensive framework encompassing dataset curation, anatomy-aware model fine-tuning, and the development of robust evaluation metrics for the RRG. By sharing our experience in 3D MLLM-based RRG, we aim to accelerate the expedition in human-machine collaboration for next-generation healthcare.